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  • Wake promoting agents: search for next generation modafinil, lessons learned: part III.

Wake promoting agents: search for next generation modafinil, lessons learned: part III.

Bioorganic & medicinal chemistry letters (2012-05-02)
Derek Dunn, Greg Hostetler, Mohamed Iqbal, Val R Marcy, Yin Guo Lin, Bruce Jones, Lisa D Aimone, John Gruner, Mark A Ator, Edward R Bacon, Sankar Chatterjee
PMID22546675
ABSTRACT

In searching for a next generation molecule to the novel wake promoting agent modafinil (compound 1), a series of fluorene-derived wakefulness enhancing agents were developed and evaluated in rat. Extensive pharmacokinetic studies of a potent member of the series (compound 15) revealed that the wake promotion activity of the analog was likely due to an active metabolite (compound 3).