- A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.
A novel pH-responsive polysaccharidic ionic complex for proapoptotic D-(KLAKLAK)2 peptide delivery.
Chemical communications (Cambridge, England) (2011-02-16)
Bo Reum Lee, Kyung Taek Oh, Young Taik Oh, Hye Jung Baik, So Young Park, Yu Seok Youn, Eun Seong Lee
PMID21321691
ABSTRACT
We report charge-switching ionic nanocomplexes comprised of glycol chitosan grafted with 2,3-dimethylmaleic acid (DMA) (denoted as 'GCS-g-DMA' hereafter) and a proapoptotic peptide. This system allowed for improved peptide delivery to tumor sites via a mechanism of selective peptide release when the pH was dropped from 7.4 to 6.8.
MATERIALS