- Water-driven ligations using cyclic amino squarates: a class of useful SN1-like reactions.
Water-driven ligations using cyclic amino squarates: a class of useful SN1-like reactions.
Chemical communications (Cambridge, England) (2010-11-18)
Dawei Cui, Deepali Prashar, Preeti Sejwal, Yan-Yeung Luk
PMID21082090
ABSTRACT
We report a class of water-soluble and -stable cyclic amino squarates that ligate with cysteine or lysine residues without side-products in an entirely aqueous environment. The ligations include addition-elimination reactions that are promoted by water in a way similar to S(N)1 reactions. The structural versatility of the reactants allows the potential recognition of selected amino acid residues on proteins.
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