Tamoxifen affects the toxicokinetics of o,p'-DDT in male Nile Tilapia (Oreochromis niloticus).

The goal of the present study was to evaluate the role of Tamoxifen (TAM), in the distribution and/or elimination kinetics of o,p'-DDT, in male tilapias. A non-compartmental analysis was chosen to describe the time course of o,p'-DDT plasma concentrations. Mean plasma concentration of o,p'-DDT following IP administration indicates a very complex kinetic profile. Tamoxifen decreased the o,p'-DDT mean half-life (t½) from 20.38 to 16.11 days, the Mean Residence Time (MRT) from 28.7 to 23.23 days, and clearance (CL) from 0.0031 to 0.001 mL/min. The distribution pattern of o,p'-DDT in tissues and the clearance in plasma suggest that storage points mediated through the membrane-receptor lipophilicity can be involved.