Physico-chemical characterization of a new salt of ibuprofen.

Physico-chemical characterization of a new salt of ibuprofen.

Journal of pharmaceutical and biomedical analysis (1990-01-01)

M S Suleiman, N M Najib, M A Hassan, M E Abdel-Hamid

ABSTRACT

A new salt of ibuprofen was prepared by reaction with t-butylamine; its formation was confirmed by IR and 1H-NMR spectroscopy. The salt was characterized by thermoanalytical, X-ray powder diffraction and solubility studies. The salt was found to be 1.5 times more soluble in water than was ibuprofen, with an enthalpy of solution of -8.84 kcal mol-1.

MATERIALS

Product Number

Brand

Product Description

391433

Sigma-Aldrich

tert-Butylamine, ≥99.5%

96328

Sigma-Aldrich

tert-Butylamine hydrochloride, ≥98.0% (AT)

B89205

Sigma-Aldrich

tert-Butylamine, 98%