- Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization.
Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization.
The Journal of organic chemistry (2006-02-14)
Dun Zhang, Xuechao Xing, Gregory D Cuny
PMID16468841
ABSTRACT
A method for the preparation of enantiomerically pure hydantoins from optically pure alpha-amino amides utilizing triphosgene is described. We also propose that the racemization observed with 1,1'-carbonyldiimidazole (CDI) for this type of reaction is due to the imidazole carbamate intermediates.