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[Reaction of pyridinium salts with active methylene compounds].

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan (2006-02-08)
Reiko Fujita, Masato Hoshino, Yasuhiro Nishiuchi, Hiroshi Tomisawa
PMID16462100
ABSTRACT

The carbon-carbon bond-forming reactions of 1-methyl-2-methylthiophenylpyridinium iodides with active methylene compounds (such as dimethyl malonate, malononitrile) using NaH as a base gave the 2-substituted methylene-1,2-dihydropyridine derivatives.

MATERIALS
Product Number
Brand
Product Description
63380
Sigma-Aldrich
Dimethyl malonate, purum, ≥96.0% (GC)
136441
Sigma-Aldrich
Dimethyl malonate, 98%