- Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.
Synthesis and activity of 2-oxoamides containing long chain beta-amino acids.
Journal of peptide science : an official publication of the European Peptide Society (2005-01-07)
Violetta Constantinou-Kokotou, Anna Peristeraki, Christoforos G Kokotos, David A Six, Edward A Dennis
PMID15635664
ABSTRACT
2-Oxoamides based on long chain beta-amino acids were synthesized. 1-Benzyl substituted long chain amines, needed for such synthesis, were synthesized starting from Boc-phenylalaninol. The oxidative conversion of a phenyl group to a carboxyl group was used as the key transformation synthetic step. The compounds synthesized were studied for their activity against GIVA PLA(2), and were proven to be weak inhibitors.
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