- Insecticidal compounds against Drosophila melanogaster from Cornus officinalis Sieb. et Zucc.
Insecticidal compounds against Drosophila melanogaster from Cornus officinalis Sieb. et Zucc.
Natural product research (2003-10-07)
Mitsuo Miyazawa, Jun Anzai, Jun Fujioka, Yukio Isikawa
PMID14526912
ABSTRACT
Dimethyl malate (1) and 5-hydroxymethyl furfural (2) were isolated as insecticidal compounds by bioassay-guided fractionation from MeOH extract of the fruits of Cornus officinalis Sieb. et Zucc. Insecticidal activity against larvae of D. melanogaster was demonstrated: 1 and 2 gave the LC50 value of 6.15 and 11.8 micromol/mL of diet concentration, respectively. Acute toxicity against adults of D. melanogaster, 1 and 2 had the insecticidal activity, with the LD50 value of 21.5 and 34.0 microg/adult.
MATERIALS