- Polyflavanostilbene A, a new flavanol-fused stilbene glycoside from Polygonum cuspidatum.
Polyflavanostilbene A, a new flavanol-fused stilbene glycoside from Polygonum cuspidatum.
Organic letters (2013-01-17)
Fushuang Li, Zhilai Zhan, Fu Liu, Yanan Yang, Li Li, Ziming Feng, Jianshuang Jiang, Peicheng Zhang
PMID23320550
ABSTRACT
Polyflavanostilbene A, a new flavanol-fused stilbene glycoside, was isolated from the rhizome of Polygonum cuspidatum. Its unusual structure, including its absolute stereochemistry, was determined by UV, IR, HRESIMS, and 1D and 2D NMR data and by the comparison of experimental and calculated electronic circular dichroism (ECD) spectra. Polyflavanostilbene A has an unprecedented rearranged flavanol skeleton fused to stilbene via a hexahydrocyclopenta[c]furan moiety. Polyflavanostilbene A showed strong inhibitory activity against α-glucosidase with an IC(50) value of 17.7 μM.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
α-Glucosidase from rice, Type V, ammonium sulfate suspension, 40-80 units/mg protein
Sigma-Aldrich
α-Glucosidase from Saccharomyces cerevisiae, recombinant, expressed in proprietary host, lyophilized powder, ≥100 units/mg protein
Sigma-Aldrich
α-Glucosidase from Saccharomyces cerevisiae, Type I, lyophilized powder, ≥10 units/mg protein (using p-nitrophenyl α-D-glucoside as substrate.)
Sigma-Aldrich
α-Glucosidase from Bacillus stearothermophilus, lyophilized powder, ≥50 units/mg protein