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  • Effects of aging-induced obesity on the transcriptional expression of adipogenesis and thermogenic activity in the gonadal white adipose, brown adipose, and skeletal muscle tissues.

Effects of aging-induced obesity on the transcriptional expression of adipogenesis and thermogenic activity in the gonadal white adipose, brown adipose, and skeletal muscle tissues.

Physical activity and nutrition (2023-08-16)
Insu Kwon, Nurul Fatihah Talib, JunShu Zhu, Hyung-In Yang, Kyoung Soo Kim
ABSTRACT

Aging is closely associated with chronic metabolic diseases, such as obesity, which lead to increased adiposity, skeletal muscle wasting, and imbalanced cellular energy metabolism. However, transcriptional profiles representing energy imbalances in aging-induced obesity are not fully understood. Thus, this study aimed to investigate the candidate genes predominantly regulated in aging-related obesity in spontaneously aged mice. Male C57BL/6J mice were divided into three age groups according to age: 2- (young), 12- (middle-aged), and 24- (old) months. Body weight and body composition parameters were measured in all mice. Gonadal white adipose tissue (gWAT), brown adipose tissue (BAT), and skeletal muscle (SM) were dissected and weighed. The target tissues were assessed using biochemical and histological assays. Aging-induced obesity increased adipose mass and decreased SM weight through processes of adipocyte hypertrophy; however, recruitment of modulating adipogenesis-inducing transcription factors did not occur. Among adipokines, leptin level was greatly increased in the gWAT during aging. Interestingly, the β2-adrenergic receptor had a higher affinity than the β3-adrenergic receptor in aging-induced obesity. For the thermogenic regulation through β-adrenergic receptors (β-ARs), a declined uncoupling protein-1 (UCP-1) in the BAT was relevant to aging-induced obesity. Aging-induced obesity increases leptin levels in adipocytes and decreases UCP-1 in BAT through β-ARs, according to transcriptional gene profiling. WAT browning increases energy expenditure due to exercise training adaptations. Further research is needed to discover more effective methods, such as exercise, against aging-induced obesity.

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Anti-GABA (No Gluteraldehyde) Antibody, Chemicon®, from rabbit
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