- SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins.
SOX9 is colocalized with paraspeckle protein NONO in cultured murine sertoli cells and features structural characteristics of intrinsically disordered proteins.
Molecular reproduction and development (2020-10-07)
Kazuhisa Akiba, Satoshi Narumi, Riko Nishimura, Yuko Kato-Fukui, Shuji Takada, Yukihiro Hasegawa, Maki Fukami
PMID33022123
ABSTRACT
This study provides supporting evidence for the association between SOX9 and liquid-liquid phase separation. We show that SOX9 colocalized with a paraspeckle protein NONO in many, but not all, of the immortalized and primary murine Sertoli cells examined. In addition, we confirmed that SOX9 has structural characteristics of intrinsically disordered proteins.
MATERIALS