- Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application.
Full spectroscopic characterization of two crystal pseudopolymorphic forms of the antiandrogen cortexolone 17α-propionate for topic application.
Steroids (2017-09-20)
Patrizia Ferraboschi, Maria Chiara Sala, Riccardo Stradi, Laura Ragonesi, Clarissa Gagliardi, Paolo Lanzarotti, Enzio M Ragg, Matteo Mori, Fiorella Meneghetti
PMID28923714
ABSTRACT
Cortexolone-17α-propionate (CP) is a topically active antiandrogen useful in the treatment of skin disorders. In the solid state, three anhydrous forms of this drug (CPI, CPII and CPIII) occur, together with one hydrated crystal (CPW). The single crystal structure of the monohydrated phase, CPW, compared with that of the anhydrous form CPIII, shows a markedly different solid state behavior. These latter pseudopolymorphic forms have also been fully characterized by spectroscopic methods.
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