- Design and synthesis of vidarabine prodrugs as antiviral agents.
Design and synthesis of vidarabine prodrugs as antiviral agents.
Bioorganic & medicinal chemistry letters (2008-12-23)
Wei Shen, Jae-Seung Kim, Phillip E Kish, Jie Zhang, Stefanie Mitchell, Brian G Gentry, Julie M Breitenbach, John C Drach, John Hilfinger
PMID19097789
ABSTRACT
5'-O-D- and L-amino acid derivatives and 5'-O-(D- and L-amino acid methyl ester phosphoramidate) derivatives of vidarabine (ara-A) were synthesized as vidarabine prodrugs. Some compounds were equi- or more potent in vitro than vidarabine against two pox viruses and their uptake by cultured cells was improved compared to the parent drug.
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