- Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
Interaction of Autotaxin With Lipoprotein(a) in Patients With Calcific Aortic Valve Stenosis.
JACC. Basic to translational science (2020-10-06)
Raphaëlle Bourgeois, Romain Devillers, Nicolas Perrot, Audrey-Anne Després, Marie-Chloé Boulanger, Patricia L Mitchell, Jakie Guertin, Patrick Couture, Michael B Boffa, Corey A Scipione, Philippe Pibarot, Marlys L Koschinsky, Patrick Mathieu, Benoit J Arsenault
PMID33015412
ABSTRACT
Our objectives were to determine whether autotaxin (ATX) is transported by lipoprotein(a) [Lp(a)] in human plasma and if could be used as a biomarker of calcific aortic valve stenosis (CAVS). We first found that ATX activity was higher in Lp(a) compared to low-density lipoprotein fractions in isolated fractions of 10 healthy participants. We developed a specific assay to measure ATX-Lp(a) in 88 patients with CAVS and 144 controls without CAVS. In a multivariable model corrected for CAVS risk factors, ATX-Lp(a) was associated with CAVS (p = 0.003). We concluded that ATX is preferentially transported by Lp(a) and might represent a novel biomarker for CAVS.