- Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Anti-angiogenic activity of basic-type, selective cyclooxygenase (COX)-1 inhibitors.
Bioorganic & medicinal chemistry letters (2006-03-04)
Hiroko Sano, Tomomi Noguchi, Atsushi Miyajima, Yuichi Hashimoto, Hiroyuki Miyachi
PMID16513348
ABSTRACT
Indole- and indoline-type basic COX-1-selective competitive inhibitors, 5-amino-1-(3,5-dimethylbenzoyl)-1H-indole (1) and 5-amino-1-(3,5-dimethylphenyl)-2,3-dihydro-1H-indole (2), were found to possess anti-angiogenic activity estimated as a tube formation-inhibition using human umbilical vein endothelial cells (HUVECs).
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