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  • Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.

Genotyping of 73 UM-SCC head and neck squamous cell carcinoma cell lines.

Head & neck (2009-09-18)
J Chad Brenner, Martin P Graham, Bhavna Kumar, Lindsay M Saunders, Robbi Kupfer, Robert H Lyons, Carol R Bradford, Thomas E Carey
PMID19760794
ABSTRACT

We established multiple University of Michigan Squamous Cell Carcinoma (UM-SCC) cell lines. With time, these have been distributed to other labs all over the world. Recent scientific discussions have noted the need to confirm the origin and identity of cell lines in grant proposals and journal articles. We genotyped the UM-SCC cell lines in our collection to confirm their unique identity. Early-passage UM-SCC cell lines were genotyped and photographed. Thus far, 73 unique head and neck UM-SCC cell lines (from 65 donors, including 21 lines from 17 females) were genotyped. In 7 cases, separate cell lines were established from the same donor. These results will be posted on the UM Head and Neck SPORE Tissue Core website for other investigators to confirm that the UM-SCC cells used in their laboratories have the correct features. Publications using UM-SCC cell lines should confirm the genotype.

MATERIALS
Product Number
Brand
Product Description
SCC076
Sigma-Aldrich
UM-SCC-22A Squamous Carcinoma Cell Line, UM-SCC-22A is a unique head and neck squamous carcinoma cell line obtained from the surgical resection of the primary cancer of the hypopharynx of a female patient and is a suitable in vitro model of H&N carcinoma studies.
SCC075
Sigma-Aldrich
UM-SCC-17B Squamous Carcinoma Cell Line, UM-SCC-17B is a unique head and neck squamous carcinoma cell line derived from the metastatic neck tumor of a 48-year old female patient and is a suitable in vitro model of H&N carcinoma studies.
SCC077
Sigma-Aldrich
UM-SCC-22B Squamous Carcinoma Cell Line, UM-SCC-22B is a unique head and neck squamous carcinoma cell line established from the metastatic lymph node in the neck of a female patient and is a suitable in vitro model of H&N carcinoma studies.
SCC074
Sigma-Aldrich
UM-SCC-17A Squamous Carcinoma Cell Line, UM-SCC-17A is a unique head and neck squamous carcinoma cell line isolated from the primary laryngeal carcinoma of a 48-year old female patient who failed to respond to radiation therapy and is a suitable in vitro model of H&N carcinoma studies.