- Enantioselective transfer aminoallylation: synthesis of optically active homoallylic primary amines.
Enantioselective transfer aminoallylation: synthesis of optically active homoallylic primary amines.
Journal of the American Chemical Society (2006-08-24)
Masaharu Sugiura, Chieko Mori, Shu Kobayashi
PMID16925417
ABSTRACT
A camphorquinone-derived chiral homoallylic amine was found to react with various aldehydes via imine formation and asymmetric 2-azonia-Cope rearrangement to give optically active homoallylic primary amines. A practical level of enantioselectivity with high functional group tolerance has been attained in this transformation.
MATERIALS