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Effect of exogenous cAMP in the rabbit right auricle.

Polish journal of pharmacology and pharmacy (1978-07-01)
W Tuganowski, P Kopeć
PMID216976
ABSTRACT

Isotonic solution of cAMP-Na was applied into spontaneously beating auricular fibres by a cut-end method. Cyclic AMP enhanced the spontaneous rate (mean 48%) and increased the contractile tension (mean 297%). These results provided direct evidence that cAMP is involved in the spontaneous activity and contraction in the heart muscle.

MATERIALS
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Product Description

Sigma-Aldrich
Adenosine 3′,5′-cyclic monophosphate sodium salt monohydrate, ≥98.0% (HPLC), powder