- Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.
Design, synthesis, and evaluation of novel boronic-chalcone derivatives as antitumor agents.
Journal of medicinal chemistry (2003-06-27)
Srinivas K Kumar, Erin Hager, Catherine Pettit, Hallur Gurulingappa, Nancy E Davidson, Saeed R Khan
PMID12825923
ABSTRACT
A series of boronic-chalcone derivatives were synthesized and tested for antitumor activity against human breast cancer cell lines. The results show the boronic-chalcones are more toxic to breast cancer cells compared to normal breast cells than other known chalcones.
MATERIALS
Product Number
Brand
Product Description
Sigma-Aldrich
MDM2 Inhibitor, The MDM2 Inhibitor, also referenced under CAS 562823-84-1, controls the biological activity of MDM2.