- N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery.
N omega-hydroxy-L-arginine: a novel arginine analog capable of causing vasorelaxation in bovine intrapulmonary artery.
Biochemical and biophysical research communications (1991-04-15)
G C Wallace, P Gulati, J M Fukuto
PMID2018542
ABSTRACT
This study describes the effects of N omega-hydroxy-L-arginine (NOHA) on endothelium dependent and endothelium independent relaxation of bovine pulmonary artery. These results are consistent with the hypothesis that NOHA is a biosynthetic intermediate in the production of nitric oxide from arginine. N omega-Hydroxy-L-arginine causes both endothelium dependent and endothelium independent vasorelaxation, similar to that of arginine. This NOHA elicited relaxation was also inhibitable by N-methylarginine, N-nitroarginine and N-aminoarginine.
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NG-Hydroxy-L-arginine, Monoacetate Salt, Cell permeable. A key intermediate in the biosynthesis of nitric oxide by cNOS. NOHA can be efficiently oxidized to nitric oxide and citrulline by cytochrome P450 system.
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