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CN
  • A multi-spectroscopic approach to investigate the interactions between Gramicidin A and silver nanoparticles.

A multi-spectroscopic approach to investigate the interactions between Gramicidin A and silver nanoparticles.

Soft matter (2019-08-01)
Marta Gambucci, Pier Luigi Gentili, Paola Sassi, Loredana Latterini
PMID31364666
ABSTRACT

The comprehension and control of the interactions between nanoparticles and proteins at a molecular level are crucial to improve biomedical applications of nanomaterials and to develop nanosystems able to influence and regulate the conformational changes in proteins. In this work, we explore the interactions between Gramicidin A peptide (GramA) and dodecanethiol-stabilized small silver nanoparticles (D-AgNPs), paying particular attention to the effect on GramA conformation in POPC bilayers. D-AgNPs have been prepared to have dimensions (5 nm) and a hydrophobic nature compatible with the POPC lipid bilayer. Fluorescence, Raman and IR spectroscopies have been used to investigate both peptide conformation and its position inside the phospholipid bilayer. Results are discussed in terms of solvent exposure and conformation of GramA peptide.