Skip to Content
Merck
CN
  • Spy vs. spy: selecting the best reporter for 19F NMR competition experiments.

Spy vs. spy: selecting the best reporter for 19F NMR competition experiments.

Chemical communications (Cambridge, England) (2019-01-16)
Guilherme Vieira de Castro, Alessio Ciulli
PMID30644956
ABSTRACT

Systematic characterization of a series of fluorinated VHL ligands, varying binding affinity and position of the trifluoromethyl group, qualifies a spy molecule for competitive 19F NMR screening and reveals guiding principles to develop highly sensitive assays with low material consumption.