- Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides.
Preparation of potassium alkoxymethyltrifluoroborates and their cross-coupling with aryl chlorides.
Organic letters (2008-04-29)
Gary A Molander, Belgin Canturk
PMID18439019
ABSTRACT
A wide variety of alkoxymethyltrifluoroborate substrates were prepared via SN2 displacement of potassium bromomethyltrifluoroborate with various alkoxides in excellent yields. These alkoxymethyltrifluoroborates were effectively cross-coupled with several aryl chlorides. This method provides a unique dissonant disconnect that allows greater flexibility in the design of new and improved synthetic pathways.