Skip to Content

Dear Customer:

The current international situation is complex and volatile, and uncertain tariff policies may potentially impact our product prices. Given these uncertainties, we value your understanding regarding order-related matters.

If you decide to place an order during this period, we reserve the right to adjust the price based on the evolving situation. We understand that market changes may cause inconvenience. We will negotiate with you if there’s a significant price fluctuation due to tariff policy changes before the order’s actual delivery, and in such cases we may adjust or cancel the order as necessary.

Merck
CN
  • Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

Chiral vinylphosphonate and phosphonate analogues of the immunosuppressive agent FTY720.

The Journal of organic chemistry (2009-03-20)
Xuequan Lu, Chaode Sun, William J Valentine, E Shuyu, Jianxiong Liu, Gabor Tigyi, Robert Bittman
ABSTRACT

The first enantioselective synthesis of chiral isosteric phosphonate analogues of FTY720 is described. One of these analogues, FTY720-(E)-vinylphosphonate (S)-5, but not its R enantiomer, elicited a potent antiapoptotic effect in intestinal epithelial cells, suggesting that it exerts its action via the enantioselective activation of a receptor. (S)-5 failed to activate the sphingosine 1-phosphate type 1 (S1P(1)) receptor.

MATERIALS
Product Number
Brand
Product Description

Sigma-Aldrich
Vinylphosphonic acid, 97%
Sign Into View Organizational & Contract Pricing
SKUPack SizeAvailabilityPriceQuantity
5 g
Available to ship on 2025年4月15日
Details...
¥698.02
25 g
Available to ship on 2025年4月15日
Details...
¥2,718.42