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  • Synergistic effects of hyaluronate - epidermal growth factor conjugate patch on chronic wound healing.

Synergistic effects of hyaluronate - epidermal growth factor conjugate patch on chronic wound healing.

Biomaterials science (2018-04-05)
Yun Seop Kim, Dong Kyung Sung, Won Ho Kong, Hyemin Kim, Sei Kwang Hahn
ABSTRACT

The proteolytic microenvironment in the wound area reduces the stability and the half-life of growth factors in vivo, making difficult the topical delivery of growth factors. Here, epidermal growth factor (EGF) was conjugated to hyaluronate (HA) to improve the long-term stability against enzymatic degradation and the therapeutic effect by enhancing the biological interaction with HA receptors on skin cells. After the synthesis of HA-EGF conjugates, they were incorporated into a patch-type formulation for the facile topical application and sustained release of EGF. According to ELISA, the HA-EGF conjugates showed a long-term stability compared with native EGF. Furthermore, HA-EGF conjugates appeared to interact with skin cells through two types of HA and EGF receptors, resulting in a synergistically improved healing effect. Taken together, we could confirm the feasibility of HA-EGF conjugates for the transdermal treatment of chronic wounds.

MATERIALS
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Sigma-Aldrich
Ethyl carbazate, 97%