Research-Grade mRNA Services
Small Scale Research-Grade mRNA Services
Our Center of Excellence in Hamburg with 15+ years experience focuses on small scale research-grade mRNA and preclinical custom mRNA manufacturing services. We mitigate risk through our small-scale research grade mRNA synthesis and screening service, delivering customized, high-quality material in quantities ranging from 0.1 mg to 1 mg for early discovery through preclinical studies.
Streamlining Research-Grade mRNA-Sourcing
Propel your next project, by leveraging our more than 15 years experience and expertise in pre-clinical mRNA manufacturing.
- We develop, optimize and manufacture your sequences including:
- Choice of CleanCap® technology capping, Enzymatic Vaccinia capping, or ARCA capping
- Use of modified nucleotides *
- Customizable poly(A) tail length
- Use of your own UTRs, or supply of our proven & tested UTRs
- Expedite your journey, through our simplified research grade mRNA packages
- Flexible manufacturing, purification and analytical packages at your service
- Milligram to gram scale batch capacity available
Let us assist you in designing your research-grade mRNA. Share your technical specifications, and one of our experts will review them and provide you with a quote.
* May be subject to customer obtaining the appropriate license(s)
Partner with us to bring transformative therapies to patients:
- State-of-the-art process development: With more than 15 years of experience, we tailor our qualified platform process to your specific mRNA sequence.
- Extensive Analytical Capabilities: Enabling success through our in-house analytical development & validation teams.
- Dedicated Project Management: Ensuring that projects are completed on time, within budget, and to the highest possible standards.
Key Features of PCR-based mRNA Manufacturing
With our proven PCR-based workflow, mRNA manufacturing is highly reproducible, leading to high quality and mRNA performance.
Through reduced product related impurities and increased mRNA homogeneity, resulting in higher stability and prolonged expression.
Ensuring high quality from the start of the process. IVT template generated in house.
Via cell free process, thereby mitigating microbial DNA, protein and endotoxin contaminants.
10,000 fold less pDNA compared to conventional linearization approach. pDNA only needed according to GMP principles.
Including flexible poly(A) tailing later during IVT template generation, circumventing truncation and pDNA yield limitations when pre-encoded.
TECHNICAL RESOURCES
- Manufacturing Strategies for mRNA Vaccines and Therapeutics
Discover considerations for mRNA manufacturing and how mRNA is made. Learn how to purify and formulate mRNA and what to consider when scaling up the mRNA manufacturing process.
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