Tangential Flow Filtration Devices
Our tangential flow filtration (TFF) products provide versatile solutions for both single-use and multi-use pharma and biopharma applications. Designed to streamline processes, these devices maximize yield and product recovery, enhancing efficiency while minimizing operational complexity. Our Pellicon® Capsules and cassettes can be used for different applications and offer options for every ultrafiltration and diafiltration challenge.
Single-pass TFF with Pellicon® capsules and cassettes
Single-pass TFF with our Pellicon® capsules and cassettes streamlines processing by concentrating process streams without the recirculation of traditional TFF. This is a simple way to increase capacity, concentration, and product recovery while improving footprint. This versatile application also enables continuous and intensified processing, in which in-line volume reduction is coupled to other process steps.
Pellicon® Capsules
Pellicon® Capsules with Ultracel® membrane combine streamlined ultrafiltration and diafiltration with ease of use and process flexibility. This innovative single-use TFF capsule delivers superior mass transfer, flux and optimum recovery in a unique plug-and-play, holderless device that comes gamma sterilized and ready to process in minutes.
Pellicon® 3 cassettes
Pellicon® 3 cassettes deliver high protein yield and consistent performance while offering broad chemical compatibility. They are available with Ultracel® and Biomax® membranes for different processing needs, including mAbs, plasma, insulin, peptides, and vaccines. To overcome the filtration challenges of high viscosity, our Pellicon® 3 cassettes with D screen are easy to use, enable faster processing and are optimized to achieve higher protein concentrations.
Pellicon® 2 cassettes
Pellicon® 2 cassettes are ideal for the ultrafiltration and diafiltration of biologics including concentration, desalting, and buffer exchange of polysaccharides, virus suspensions, and protein solutions. Our Ultracel® and Biomax® membranes offer efficient ultrafiltration while Durapore® membrane is best suited for microfiltration.
Pellicon® XL 50 cassettes
Pellicon® XL 50 cassettes couple our ultrafiltration and microfiltration membranes with linear scalability for process development or small-volume processing.
Prostak™ microfiltration modules
Prostak™ microfiltration modules provide robust construction, reliable performance, and steam-in-place capability, making them suitable for clarification, cell harvest, and multi-use perfusion. The low hold-up volume and open channel design allow high product recovery and gentle flow path for processing shear-sensitive materials.
Support for qualification, risk assessment, and process optimization
Complementing our product portfolio, the Emprove® Program provides three types of dossiers to support different stages of development and manufacturing operations such as qualification, risk assessment, and process optimization. The dossiers consolidate comprehensive product-specific testing data, quality statements, and regulatory information in a readily available format to simplify your compliance needs.
Related Webinars
Guidance and best practices for assessing different approaches to maximize the benefits of SPTFF concentration and improved productivity of an intensified protein A capture step.
This webinar presents the challenges arising from highly concentrated protein solutions during formulation by TFF as well as the impact of the TFF cassette design and the benefits or viscosity-reducing excipient combination during TFF
This webinar discusses the implementation of closed processing for downstream applications and present the design and performance testing of a single-use manufacturing-scale tangential flow filtration system to be able to operate in both functionally and fully closed mode.
An overview of single-use TFF capsules for single-pass tangential flow filtration (SPTFF) of mAbs and other therapeutic proteins.
Related articles
- There are many options for tangential flow filtration (TFF) in downstream bioprocessing from multi-use to single-use TFF or batch TFF and single-pass TFF.
- Find best practices for using Pellicon® Capsules in ADC processing as well as data from two studies using Pellicon® Capsules and Pellicon® cassettes in the ADC manufacturing process.
- Get practical guidance on using single-pass tangential flow filtration in your downstream process and scaling between capsules and cassettes.
Related Documents
- Application note: Best practices for permeate-controlled tangential flow filtration
Process development and optimization for robust permeate-controlled TFF using microfiltration and open-ultrafiltration membranes.
- Performance guide: Pellicon® capsules with 100 and 300 kDa Ultracel® membrane
Single-use tangential flow filtration devices offering high flux performance, reliable scalability, and enhanced operator safety for viral gene therapy applications.
- Data sheet: Pellicon® capsules with Ultracel® membrane
Accelerate your therapy using our innovative single-use tangential flow filters with superior flux performance
- Data sheet: Pellicon® 3 cassettes with Ultracel® membrane
The optimum tangential flow filtration devices for monoclonal antibodies and other therapeutic proteins.
- Data sheet: Pellicon® 3 cassettes with Biomax® membrane
The device of choice for applications requiring higher yield, fast processing, and exceptional chemical resistance
- Data sheet: Pellicon® 2 filters and holders
High performance tangential flow filters for biopharmaceutical process development, scale-up and scale-down, concentration, purification, and cell harvesting applications.
- Data sheet: Prostak™ microfiltration modules
Prostak™ modules are tangential flow stacked plate membrane devices with open feed channels, made for use in Prostak™ tangential flow filtration (TFF) systems.
- Data sheet: Pellicon® XL 50 cassettes
Easy-to-use, high performance, linearly scalable tangential flow filtration cassette for process development work at volumes from 50 to 1000 mL
- Data sheet: Pellicon® single-pass tangential flow filtration
Pellicon® single-pass tangential flow filtration (single-pass TFF) is a versatile technology for more productive, high capacity and cost effective downstream processes that allows facilities to meet the demands of higher titer and connected or continuous processes
- Data sheet: Ultracel® membranes
The membrane of choice for ultra-low protein binding and robust performance during concentration and diafiltration of therapeutics
- Data sheet: Biomax® membranes
The membrane of choice for fast processing and exceptional chemical resistance
- Performance guide: Pellicon® capsules with Ultracel® membrane
Innovative, high performance single-use tangential flow filtration devices that offer ease-of-use, operational flexibility, and enhanced operator safety.
- Application note: Pellicon® capsules for single-use tangential flow filtration
The Pellicon® Capsule is the first of its kind—a true single-use TFF device that streamlines bioprocessing with its innovative, simplified design and user-friendly features.
- Performance guide: Pellicon® 3 cassettes with Ultracel® membrane
The tangential flow filtration devices of choice for demanding filtration processes requiring unbeatable performance consistency.
- Performance guide: Pellicon® 3 cassettes with Biomax® membrane
The tangential flow filtration device of choice for demanding filtration processes requiring unbeatable performance consistency
- Application note: Pellicon® 3 cassettes with high viscosity feed screen
Pellicon® 3 Cassettes with Ultracel® and Biomax® 30kD Membrane utilizing D screen geometry are engineered to efficiently process higher viscosity products.
- Application note: Process optimization and scalability evaluation of Pellicon® capsules for single-pass tangential flow filtration of mAb-based biomolecules
Single-pass tangential flow filtration (SPTFF) is a method of ultrafiltration for the purposes of either volume reduction or protein concentration.
- White paper: Streamlining bioprocessing using Pellicon® cassettes for single-pass operation
Single-pass TFF is an enhanced approach to the existing TFF technology that has been used for the purification of monoclonal antibodies, therapeutic proteins, and vaccines at different steps within downstream processing
- Application note: Closed tangential flow filtration processing at benchtop scale with Mobius® assemblies
Mobius® assemblies offer a customizable, closed processing option for tangential flow filtration (TFF) operations.
- Application note: Pellicon® 3 cassettes with Ultracel® membrane performance guide
The tangential flow filtration devices of choice for demanding filtration processes requiring unbeatable performance consistency.
Related video
Pellicon® capsule how is it made and how does it work?
See what makes the Pellicon® Capsule a true single-use TFF device that comes ready to process mAbs and ADCs in minutes.
