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Merck
CN

S0375

Sigma-Aldrich

D-Saccharic acid 1,4-lactone monohydrate

≥98.0% (HPLC)

Synonym(s):

D-Glucaric acid-1,4-lactone, D-Saccharolactone

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Estimated to ship on2025年9月09日Details


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1 VIAL
¥678.00
5 X 1 VIAL
¥3,029.15

About This Item

Empirical Formula (Hill Notation):
C6H8O7 · H2O
CAS Number:
Molecular Weight:
210.14
Beilstein:
85594
MDL number:
UNSPSC Code:
12352201
PubChem Substance ID:
NACRES:
NA.25

¥678.00


Estimated to ship on2025年9月09日Details


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Quality Level

Assay

≥98.0% (HPLC)

form

powder

impurities

≤10.0% water (Karl Fischer)

color

white

mp

91 - 93 °C ((196 - 199 °F ))

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

2-8°C

SMILES string

O.O[C@@H]1[C@@H](O)C(=O)O[C@@H]1[C@H](O)C(O)=O

InChI

1S/C6H8O7.H2O/c7-1-2(8)6(12)13-4(1)3(9)5(10)11;/h1-4,7-9H,(H,10,11);1H2/t1-,2-,3+,4+;/m1./s1

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1 of 4

This Item
85145079469L254
assay

≥98.0% (HPLC)

assay

≥99%

assay

≥97.0% (HPLC)

assay

-

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

200

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

solubility

water: soluble 25 mg/mL, clear, colorless

solubility

-

solubility

-

form

powder

form

powder

form

crystals

form

powder

storage temp.

2-8°C

storage temp.

-

storage temp.

−20°C

storage temp.

-

color

white

color

-

color

white

color

-

General description

D-Saccharic acid 1,4-lactone monohydrate (DSAL) has an ability to inhibit the activity of β-glucuronidase enzyme.[1]It also potentially inhibits Klotho deglycosylation of excitatory amino acid transporters (EAATs) and peptide transporters (PEPTs).[2]

Application

D-Saccharic acid 1,4-lactone monohydrate has been used as a constituent of phosphate buffer to block incidental β-glucuronidase activity in Streptococcus pneumoniae hyaluronan lyase (SpnHL) activity assay.[3] It has also been used as a component of reaction mixture in Iduronidase activity assay[4] and UDP-glucuronosyltransferase 1 (UGT1A1) inhibition assay.[5]

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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beta-Klotho as a Negative Regulator of the Peptide Transporters PEPT1 and PEPT2
Abousaab A, et al.
Cellular Physiology and Biochemistry, 40(5), 874-882 (2016)
Syed Ahmad et al.
Current chemical genomics, 5, 13-20 (2011-06-07)
CPT-11 is a widely-used anti-cancer drug that is converted in vivo to its active metabolite, SN-38. In the liver, enzymes detoxify SN-38 by coupling it to a glucuronidate moiety and this inactive compound (SN-38G) is excreted into the gastrointestinal tract.
Gertrud E Morlock et al.
Antioxidants (Basel, Switzerland), 10(1) (2021-01-21)
The antioxidative activity of Camelia sinensis tea and especially powdered tea extracts on the market, among others used as added value in functional foods, can considerably vary due to not only natural variance, but also adulteration and falsification. Thus, an
Magnetic macroporous bead cellulose functionalised with recombinant hyaluronan lyase for controllable hyaluronan fragmentation
Kavsparova J, et al.
Process Biochemistry (Oxford, United Kingdom), 72, 105-111 (2018)
Klotho preservation by Rhein promotes toll-like receptor 4 proteolysis and attenuates lipopolysaccharide-induced acute kidney injury
Bi F, et al.
Journal of Molecular Medicine, 96(9), 915-927 (2018)

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