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D6821

Sigma-Aldrich

Donepezil hydrochloride

≥98% (HPLC), powder, acetylcholinesterase inhibitor

Synonym(s):

1H-Inden-1-one, 2,3-dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methyl]-, hydrochloride, E2020

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0.2 ML
¥8,960.87

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Available to ship on2025年4月23日Details

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0.2 ML
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About This Item

Empirical Formula (Hill Notation):
C24H29NO3 · HCl
CAS Number:
120011-70-3
Molecular Weight:
415.95
MDL number:
MFCD00881312
UNSPSC Code:
12352200
PubChem Substance ID:
329798838
NACRES:
NA.77

¥8,960.87

Available to ship on2025年4月23日Details

Request a Bulk Order

Product Name

Donepezil hydrochloride, ≥98% (HPLC)

Quality Level

100

Assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white to off-white

solubility

DMSO: ≥20 mg/mL
H2O: ≥20 mg/mL

storage temp.

room temp

SMILES string

O=C1C(CC2CCN(CC3=CC=CC=C3)CC2)CC4=CC(OC)=C(OC)C=C41.[H]Cl

InChI

1S/C24H29NO3.ClH.H2O/c1-27-22-14-19-13-20(24(26)21(19)15-23(22)28-2)12-17-8-10-25(11-9-17)16-18-6-4-3-5-7-18;;/h3-7,14-15,17,20H,8-13,16H2,1-2H3;1H;1H2

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SU860103

Magnetic Screw Cap for Headspace Vials, 18 mm thread

Universal Screw Cap, ND18 for Headspace Vials Ultra-clean, solid-top cap, septum thickness 1.3 mm

SU860174

Universal Screw Cap, ND18 for Headspace Vials

Magnetic Screw Cap for Headspace Vials, 18 mm thread PTFE-faced butyl septum (grey PTFE/red Butyl), septum thickness 1.6 mm, pkg of 100 ea

SU860102

Magnetic Screw Cap for Headspace Vials, 18 mm thread

material

PTFE/silicone septum (white PTFE/tranparent blue silicone), stainless steel screw cap (magnetic, open-top, 8 mm center hole)

material

PTFE/silicone septum (white PTFE/blue silicone), stainless steel screw cap (magnetic, open-top, 8 mm center hole)

material

red PTFE/white silicone septa, stainless steel screw cap (magnetic)

material

PTFE-faced butyl septum (grey PTFE/red Butyl), stainless steel screw cap (magnetic, open-top, 8 mm center hole)

fitting

thread for 18 mm

fitting

thread for 18 mm

fitting

thread for screw cap headspace vial (ND18)

fitting

thread for 18 mm

hardness

35 (Durometer: shore A)

hardness

60 (Durometer: shore A, durometer)

hardness

45 (Durometer: shore A)

hardness

55 (Durometer: shore A)

packaging

pkg of 100 ea

packaging

pkg of 100 ea

packaging

pkg of 1 × 100 ea (SU860174)

packaging

pkg of 100 ea

O.D. × H

18 mm × 11 mm

O.D. × H

18 mm × 11 mm

O.D. × H

-

O.D. × H

18 mm × 11 mm

Application

Donepezil hydrochloride has been used in dose-response experiment to study its efficacy in ameliorating nicotine withdrawal-induced deficits in contextual conditioning in mice.[1] It has also been intraperitoneally injected into rats to study its ability to improve social behavioral deficits, repetitive behavior and hyperactivity.[2]

Biochem/physiol Actions

Donepezil hydrochloride is a piperidine containing an organic compound and a non-competitive inhibitor.[3] It is useful in treating Alzheimer′s disease, in which dementia is a prominent symptom.[4] Donepezil is shown to induce cognitive ability and overall body function. It has a half-life of 70 hours.[5]
Donepezil monohydrochloride monohydrate is a centrally acting reversible acetylcholinesterase inhibitor.
Donepezil monohydrochloride monohydrate is a reversible acetylcholinesterase inhibitor

Features and Benefits

This compound is featured on the Acetylcholine Synthesis and Metabolism page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H300,H319

Hazard Classifications

Acute Tox. 2 Oral - Eye Irrit. 2

Storage Class Code

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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    Certificates of Analysis (COA)

    Lot/Batch Number
    0000377033
    0000377033
    0000291772
    0000192662
    0000123034

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    Donepezil for dementia due to Alzheimer's disease
    Birks Jacqueline S and Harvey Richard J
    Cochrane database of systematic reviews (Online), 6 (2018)
    Haneul Kim et al.
    Journal of ethnopharmacology, 211, 38-46 (2017-09-18)
    The seeds of Ziziphus jujuba var. spinosa (Bunge) Hu ex H.F Chow (Rhamnaceae) and the roots of Codonopsis lanceolata (Siedbold & Zucc.) Benth. & Hook. f ex Trautv. (Campanulaceae), contained in the DHP1402, have long been used for treating dementia
    Gilbert Audira et al.
    Biomolecules, 10(9) (2020-09-24)
    Donepezil (DPZ) is an acetylcholinesterase inhibitor used for the clinical treatment of mild cognitive impairment. However, DPZ has been reported to have adverse effects, including causing abnormal cardiac rhythm, insomnia, vomiting, and muscle cramps. However, the existence of these effects
    Rachel L Poole et al.
    Behavioral neuroscience, 128(5), 588-593 (2014-06-10)
    Withdrawal from chronic nicotine is associated with cognitive deficits. Therapies that ameliorate cognitive deficits during withdrawal aid in preventing relapse during quit attempts. Withdrawal-induced deficits in contextual learning are associated with nicotinic acetylcholine receptor upregulation. The aim of the present
    Ji Hyun Kim et al.
    Nutrients, 12(5) (2020-05-14)
    Obesity increases risk of Alzheimer's Disease (AD). A high fat diet (HFD) can lead to amyloidosis and amyloid beta (Aβ) accumulation, which are hallmarks of AD. In this study, protective effects of the ethyl acetate fraction of Acer okamotoanum (EAO)
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