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Merck
CN

V0377

[Arg8]-Vasopressin solution

Grade VI (synthetic), ~100 IU/mL in 0.9% NaCl

Synonym(s):

β-Hypophamine, AVP, Antidiuretic hormone, Arginine vasopressin

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About This Item

Empirical Formula (Hill Notation):
C46H65N15O12S2
CAS Number:
113-79-1
Molecular Weight:
1084.23
NACRES:
NA.32
PubChem Substance ID:
24900692
UNSPSC Code:
51111800
MDL number:
MFCD00076738
Biological source:
synthetic (organic)
Form:
liquid

Key Documents

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Product Name

[Arg8]-Vasopressin solution, Grade VI (synthetic), ~100 IU/mL in 0.9% NaCl

InChI

1S/C46H65N15O12S2/c47-27-22-74-75-23-33(45(73)61-17-5-9-34(61)44(72)56-28(8-4-16-53-46(51)52)39(67)54-21-37(50)65)60-43(71)32(20-36(49)64)59-40(68)29(14-15-35(48)63)55-41(69)31(18-24-6-2-1-3-7-24)58-42(70)30(57-38(27)66)19-25-10-12-26(62)13-11-25/h1-3,6-7,10-13,27-34,62H,4-5,8-9,14-23,47H2,(H2,48,63)(H2,49,64)(H2,50,65)(H,54,67)(H,55,69)(H,56,72)(H,57,66)(H,58,70)(H,59,68)(H,60,71)(H4,51,52,53)

SMILES string

NC1CSSCC(NC(=O)C(CC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(Cc2ccccc2)NC(=O)C(Cc3ccc(O)cc3)NC1=O)C(=O)N4CCCC4C(=O)NC(CCCNC(N)=N)C(=O)NCC(N)=O

InChI key

KBZOIRJILGZLEJ-UHFFFAOYSA-N

biological source

synthetic (organic)

sterility

non-sterile

type

Grade VI (synthetic)

form

liquid

contains

0.4% 4-chlorobutanol as preservative

concentration

~100 IU/mL in 0.9% NaCl

pH

~3.5

UniProt accession no.

P01185

shipped in

ambient

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... AVP(551)

Related Categories

Application

[Arg8]-Vasopressin solution was used as an antigen for preparing preadsorbed antisera for immunocytochemistry. The product was used in L6 cell culture of the C5 subclone for differentiation studies.

Biochem/physiol Actions

Endogenous antidiuretic hormone in most mammalian species. It is released into the blood from nerve terminals in the posterior pituitary and median eminence. Arg8-vasopressin is also a neurotransmitter in the central nervous system. It is implicated in a variety of physiological processes including diuresis, vasoregulation, and memory. Regulates water balance by antidiuretic action; contracts arterioles (vasopressor action).
Endogenous antidiuretic hormone in most mammalian species; neurotransmitter in the central nervous system implicated in a variety of physiological processes including diuresis, vasoregulation, and memory.
[Arg8]-Vasopressin solution also known as Antidiuretic hormone, Arginine vasopressin or beta-Hypophamine is a selective and potent vasopressor agent that stabilizes the cardiocirculatory function in normal human as well as in patients suffering from catecholamine-resistant vasodilatory shock. It stimulates three acid-base transporters and hence increases the capability of the cell to regulate pH.

Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

235.4 °F - closed cup

flash_point_c

113 °C - closed cup

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000484792
0000484792
0000481313
0000481313
0000438078

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J J McDonnell et al.
The Anatomical record, 240(4), 528-536 (1994-12-01)
Beta-endorphin and oxytocin immunocytochemical localization were examined in the neurointermediate lobe (lobus nervosus and pars intermedia) of the bovine hypophysis in order to describe the anatomical distribution of these two neurointermediate lobe hormones. Twenty-seven bovine hypophyses were collected from slaughterhouse
Natalie Yuen et al.
American journal of physiology. Cell physiology, 306(10), C931-C942 (2014-03-22)
Brain edema forms rapidly in the early hours of ischemic stroke by increased secretion of Na, Cl, and water into the brain across an intact blood-brain barrier (BBB), together with swelling of astrocytes as they take up the ions and
Vasopressin antagonists for patients with acute heart failure: interpreting new clinical and translational data.
A M Feldman et al.
Clinical pharmacology and therapeutics, 95(4), 373-375 (2013-12-19)
Daniel J van Wamelen et al.
Sleep, 36(1), 117-125 (2013-01-05)
To study whether sleep and circadian rhythm disturbances in patients with Huntington's disease (HD) arise from dysfunction of the body's master clock, the hypothalamic suprachiasmatic nucleus. Postmortem cohort study. Eight patients with HD and eight control subjects matched for sex
Lone Brønd et al.
American journal of physiology. Renal physiology, 305(11), F1547-F1554 (2013-10-04)
A number of studies have shown that rats with congestive heart failure (CHF) have increased protein levels of the vasopressin (AVP)-regulated water channel aquaporin-2 (AQP2) even during conditions with unchanged circulating levels of AVP, suggesting an increase in the sensitivity
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