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T5251

D-(+)-Trehalose dihydrate

Name: <SC>D</SC>-(+)-Trehalose dihydrate
Brand: SIGMA

≥98.5% (HPLC), from Saccharomyces cerevisiae

Synonym(s):

α,α-Trehalose dihydrate, D-Trehalose dihydrate, α,α-Trehalose, α-D-Glucopyranosyl-α-D-glucopyranoside

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₂₂O₁₁ · 2H₂O

CAS Number:

6138-23-4

Molecular Weight:

378.33

UNSPSC Code:

12352201

NACRES:

NA.25

PubChem Substance ID:

57654674

EC Number:

202-739-6

Beilstein/REAXYS Number:

5322018

MDL number:

MFCD00071594

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Properties

biological source

Saccharomyces cerevisiae

Quality Level

300

assay

≥98.5% (HPLC)

form

powder

optical activity

[α]/D 174 to 182 °, c = 1.0% (w/v) in water

technique(s)

HPLC: suitable, cryopreservation: suitable

mp

97-99 °C

application(s)

agriculture
cell analysis
genomic analysis
life science and biopharma

SMILES string

[H]O[H].[H]O[H].OC[C@H]1O[C@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H22O11.2H2O/c13-1-3-5(15)7(17)9(19)11(21-3)23-12-10(20)8(18)6(16)4(2-14)22-12;;/h3-20H,1-2H2;2*1H2/t3-,4-,5-,6-,7+,8+,9-,10-,11-,12-;;/m1../s1

InChI key

DPVHGFAJLZWDOC-PVXXTIHASA-N

Description

General description

D-(+)-Trehalose, a disaccharide, acts as a chemical chaperone and serves as a carbohydrate reserve in microorganisms. It functions as an osmolyte, safeguarding cells against various environmental stresses. Further, it also plays a crucial role in protein stabilization during freeze drying, making it a valuable asset in the areas of biochemical, cell culture, and excipient research

Application

Use as a cryoprotectant in a variety of cell freezing media
Used in excipeint research

Biochem/physiol Actions

Trehalose is a non-reducing sugar formed from two glucose units joined by a 1-1 alpha bond. It is thought to provide plants and animals with the ability to withstanding periods of dehydration.

Features and Benefits

Prepared from Saccharomyces cerevisiae
Suitable for use with HPLC and GC-MS(4)

Preparation Note

Prepared by the modified procedure of Payen, R., Can. J. Res., 27B, 749 (1949).

Other Notes

For additional information on our range of Biochemicals, please complete this form.

To gain a comprehensive understanding of our extensive range of Disaccharides for your research, we encourage you to visit our Carbohydrates Category page.

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Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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Articles

Pharmaceutical Research Applications of Carbohydrates and Polysaccharides

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Explore how carbohydrates function as excipients and carriers in drug delivery, with insights into mechanisms, case studies, and future trends.

The Inclusion of Chitosan in Poly-ε-caprolactone Nanoparticles: Impact on the Delivery System Characteristics and on the Adsorbed Ovalbumin Secondary Structure.

Sandra Jesus et al.

AAPS PharmSciTech, 19(1), 101-113 (2017-06-15)

This report extensively explores the benefits of including chitosan into poly-ε-caprolactone (PCL) nanoparticles (NPs) to obtain an improved protein/antigen delivery system. Blend NPs (PCL/chitosan NPs) showed improved protein adsorption efficacy (84%) in low shear stress and aqueous environment, suggesting that

Trehalose is a potent PCR enhancer: lowering of DNA melting temperature and thermal stabilization of taq polymerase by the disaccharide trehalose

Andrej-Nikolai S

Clinical Chemistry, 50, 1256-1259 (2004)

Study of longitudinal dynamics of trehalose?water solutions by inelastic ultraviolet scattering

A. Cesaro et al.

Philosophical Magazine, 87, 623-630 (2007)

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Global Trade Item Number

SKU	GTIN
T5251-25G	04061837347306
T5251-100G	04061837347276
T5251-10G	04061837347283
T5251-250G	04061837347290