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Merck
CN

N4143

Neurokinin B

≥95% (HPLC)

Synonym(s):

β-Neurokinin, Neuromedin K

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About This Item

Empirical Formula (Hill Notation):
C55H79N13O14S2
CAS Number:
86933-75-7
Molecular Weight:
1210.42
NACRES:
NA.32
PubChem Substance ID:
24897694
UNSPSC Code:
51111800
MDL number:
MFCD00133665

Key Documents

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Product Name

Neurokinin B, ≥95% (HPLC)

InChI

1S/C55H79N13O14S2/c1-30(2)21-38(50(77)62-36(47(57)74)17-19-83-5)61-43(69)28-59-55(82)46(31(3)4)68-54(81)40(23-33-15-11-8-12-16-33)65-51(78)39(22-32-13-9-7-10-14-32)64-53(80)42(26-45(72)73)67-52(79)41(24-34-27-58-29-60-34)66-49(76)37(18-20-84-6)63-48(75)35(56)25-44(70)71/h7-16,27,29-31,35-42,46H,17-26,28,56H2,1-6H3,(H2,57,74)(H,58,60)(H,59,82)(H,61,69)(H,62,77)(H,63,75)(H,64,80)(H,65,78)(H,66,76)(H,67,79)(H,68,81)(H,70,71)(H,72,73)

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(NC(=O)C(Cc1ccccc1)NC(=O)C(Cc2ccccc2)NC(=O)C(CC(O)=O)NC(=O)C(Cc3cnc[nH]3)NC(=O)C(CCSC)NC(=O)C(N)CC(O)=O)C(C)C)C(N)=O

InChI key

NHXYSAFTNPANFK-UHFFFAOYSA-N

assay

≥95% (HPLC)

form

powder

UniProt accession no.

Q9UHF0

storage temp.

−20°C

Quality Level

200

Gene Information

human ... TAC3(6866)

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Biochem/physiol Actions

Neurokinin B is a ten-residue peptide. It is an endogenous tachykinin agonist with preference for the NK-3 receptor. It is a potent bronchoconstrictor and may have a neuromodulatory role in the brain. Neurokinin B has a role in slow synaptic or non-synaptic communication.

Other Notes

Lyophilized from 0.1% TFA in H2O

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品
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Certificates of Analysis (COA)

Lot/Batch Number
0000435218
0000435218
0000226747
0000226749
0000226538

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Robert P Millar et al.
Nature reviews. Endocrinology, 9(8), 451-466 (2013-07-03)
Reproductive hormones affect all stages of life from gamete production, fertilization, fetal development and parturition, neonatal development and puberty through to adulthood and senescence. The reproductive hormone cascade has, therefore, been the target for the development of numerous drugs that
Emilie Caron et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 32(33), 11486-11494 (2012-08-17)
It is increasingly accepted that alterations of the early life environment may have lasting impacts on physiological functions. In particular, epidemiological and animal studies have indicated that changes in growth and nutrition during childhood and adolescence can impair reproductive function.
Neurokinin B Acts via the Neurokinin-3 Receptor in the Retrochiasmatic Area to Stimulate Luteinizing Hormone Secretion in Sheep
Endocrinology (2010)
The Tachykinin Peptide Neurokinin B Binds Copper Forming an Unusual [CuII(NKB)2] Complex and Inhibits Copper Uptake into 1321N1 Astrocytoma Cells
ACS Chemical Neuroscience (2013)
Neurokinin B- and specific tachykinin NK3 receptor agonists-induced airway hyperresponsiveness in the guinea-pig
Samira D
British Journal of Pharmacology (2000)
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