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N2165

Sigma-Aldrich

NKY80

≥98% (HPLC)

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Synonym(s):
2-Amino-7-(2-furanyl)-7,8-dihydro-5(6H)-quinazolinone
Empirical Formula (Hill Notation):
C12H11N3O2
CAS Number:
299442-43-6
Molecular Weight:
229.23
MDL number:
MFCD02026323
UNSPSC Code:
41106305
PubChem Substance ID:
329818599
NACRES:
NA.77

Assay

≥98% (HPLC)

form

powder

color

off-white to light brown

solubility

DMSO: ≥30 mg/mL

storage temp.

2-8°C

SMILES string

Nc1ncc2C(=O)CC(Cc2n1)c3ccco3

InChI

1S/C12H11N3O2/c13-12-14-6-8-9(15-12)4-7(5-10(8)16)11-2-1-3-17-11/h1-3,6-7H,4-5H2,(H2,13,14,15)

InChI key

SOJUSNIBPPMLCC-UHFFFAOYSA-N

Biochem/physiol Actions

NKY80 is a selective adenylyl cyclase-V inhibitor with greater than 200-fold selectivity for type V over the type II isoform.

Features and Benefits

This compound is a featured product for ADME Tox and Cyclic Nucleotide research. Discover more featured ADME Tox and Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Adenylyl cyclases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Regulatory Information

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Sung-Chul Lim et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 21(4), 397-405 (2017-07-15)
MDL-12330A is a widely used adenylyl cyclase (AC) inhibitor that blocks AC/cAMP signaling. In this study, we demonstrated a novel antitumor activity of this drug in gastric carcinoma (GC) cell lines. In these GC cells, MDL-12330A reduced cell viability and
Seyedeh Minoo Sajjadian et al.
Open biology, 10(10), 200197-200197 (2020-10-22)
In insect midgut, prostaglandins (PGs) play a crucial role in defending bacterial and malarial pathogens. However, little is known about the PG signalling pathway in the midgut. A dual oxidase (Se-Duox) with presumed function of catalysing reactive oxygen species (ROS)
Sören Brandenburg et al.
Journal of molecular and cellular cardiology, 165, 141-157 (2022-01-17)
Axial tubule junctions with the sarcoplasmic reticulum control the rapid intracellular Ca2+-induced Ca2+ release that initiates atrial contraction. In atrial myocytes we previously identified a constitutively increased ryanodine receptor (RyR2) phosphorylation at junctional Ca2+ release sites, whereas non-junctional RyR2 clusters
Adrian P Mansini et al.
Hepatology (Baltimore, Md.), 69(4), 1582-1598 (2018-10-10)
Cholangiocytes, the epithelial cells lining the biliary tree in the liver, express primary cilia that can detect several kinds of environmental signals and then transmit this information into the cell. We have reported that cilia are significantly reduced in cholangiocarcinoma
Wei Zhang et al.
Frontiers in cellular neuroscience, 13, 152-152 (2019-05-10)
Morphological and functional polarization of neurons depends on the generation and maintenance of the axon initial segment (AIS). This axonal domain maintains axonal properties but is also the place where the action potential (AP) is generated. All these functions require
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