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N2127

4-Nitrophenyl α-D-mannopyranoside

Name: 4-Nitrophenyl &#945;-<SC>D</SC>-mannopyranoside
Brand: SIGMA

α-mannosidase substrate, chromogenic, ≥98% (TLC), powder

Synonym(s):

4-Nitrophenyl a-D-mannopyranoside, 4-Nitrophenyl alpha-D-mannopyranoside, pNP-alpha-D-Man, pNPalphaMan

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₅NO₈

CAS Number:

10357-27-4

Molecular Weight:

301.25

NACRES:

NA.32

PubChem Substance ID:

24897554

UNSPSC Code:

12352204

EC Number:

233-776-6

MDL number:

MFCD00066002

Beilstein/REAXYS Number:

92210

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Properties

Product Name

4-Nitrophenyl α-D-mannopyranoside, α-mannosidase substrate

Quality Level

300

assay

≥98% (TLC)

form

powder

solubility

DMF: 50 mg/mL

storage temp.

−20°C

SMILES string

OC[C@H]1O[C@H](Oc2ccc(cc2)[N+]([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1O

InChI

1S/C12H15NO8/c14-5-8-9(15)10(16)11(17)12(21-8)20-7-3-1-6(2-4-7)13(18)19/h1-4,8-12,14-17H,5H2/t8-,9-,10+,11+,12+/m1/s1

InChI key

IFBHRQDFSNCLOZ-GCHJQGSQSA-N

Description

General description

4-Nitrophenyl α-D-mannopyranoside is a chromogenic substrate for α-mannosidase.

Application

4-Nitrophenyl α-D-mannopyranoside has been used as a substrate for α-mannosidase in hydrolase activity assay.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

涉药品监管产品

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[Inhibition of peritoneal bacterial adhesion using oligosaccharides. An experimental model of peritonitis in rats].

I Sielezneff et al.

Chirurgie; memoires de l'Academie de chirurgie, 124(2), 159-164 (1999-06-01)

Peritoneal colonization is a crucial event in the pathogenesis of peritonitis and its local complications. Adherence to the serosal mesothelium is mediated in a number of microorganisms derived from the digestive tract (especially E. coli) by type-1 fimbriae which have

Synthesis and evaluation of two mannosamine-derived lactone-type inhibitors of snail beta-mannosidase

Terinek M and Vasella A

Tetrahedron Asymmetry, 16, 449-469 (2005)

Mechanistic insights into a Ca2+-dependent family of alpha-mannosidases in a human gut symbiont.

Yanping Zhu et al.

Nature chemical biology, 6(2), 125-132 (2010-01-19)

Colonic bacteria, exemplified by Bacteroides thetaiotaomicron, play a key role in maintaining human health by harnessing large families of glycoside hydrolases (GHs) to exploit dietary polysaccharides and host glycans as nutrients. Such GH family expansion is exemplified by the 23

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Global Trade Item Number

SKU	GTIN
N2127-1G	04061826691878
N2127-500MG	04061832918075
N2127-25MG	04061832918068
N2127-100MG	04061834110149
N2127-250MG	04061832918051
N2127-5G	04061832918082