M7633
4-Methylumbelliferyl α-D-galactopyranoside
≥98% (TLC)
Synonym(s):
MU-alpha-GAL
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About This Item
Empirical Formula (Hill Notation):
C16H18O8
CAS Number:
Molecular Weight:
338.31
UNSPSC Code:
12352204
NACRES:
NA.32
PubChem Substance ID:
EC Number:
254-031-1
Beilstein/REAXYS Number:
94674
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
solubility
water: 50 mg/mL, clear, colorless to very faintly yellow
fluorescence
λex 317 nm; λem 374 nm (pH 9.1), λex 360 nm; λem 449 nm (Reaction product)
storage temp.
−20°C
SMILES string
CC1=CC(=O)Oc2cc(O[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)ccc12
InChI
1S/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13+,14+,15-,16+/m1/s1
InChI key
YUDPTGPSBJVHCN-CHUNWDLHSA-N
Application
4-Methylumbelliferyl α-D-galactopyranoside has been used as an artificial substrate to assay α-galactosidase-A activity.
Biochem/physiol Actions
4-Methylumbelliferyl α-D-galactopyranoside is a fluorogenic substrate for α-galactosidase-A. The enzyme converts the substrate to form a blue fluorescent product, methylumbelliferyl. The fluorescence is measured spectrophotometrically.
Preparation Note
4-Methylumbelliferyl α-D-galactopyranoside is soluble in water (50 mg/ml), yielding a clear, colorless to faint yellow solution with the application of heat.
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Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
涉药品监管产品
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Related Content
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Journal of laboratory automation, 19(2), 153-162 (2013-09-14)
This study illustrates how optimization of both liquid-handling accuracy and precision is critical to assay performance. The study was designed to examine (1) liquid-handling performance and (2) the effect of liquid-handling variability on two types of in vitro biochemical assays
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Molecular genetics and metabolism, 114(2), 259-267 (2014-08-27)
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Zhen-Dan Shi et al.
Analytical and bioanalytical chemistry, 394(7), 1903-1909 (2009-06-13)
Alpha-galactosidase A hydrolyzes the terminal alpha-galactosyl moieties from glycolipids and glycoproteins in lysosomes. Mutations in alpha-galactosidase cause lysosomal accumulation of the glycosphingolipid, globotriaosylceramide, which leads to Fabry disease. Small-molecule chaperones that bind to mutant enzyme proteins and correct their misfolding
Global Trade Item Number
| SKU | GTIN |
|---|---|
| M7633-250MG | 04061835557738 |
| M7633-100MG | 04061835546176 |
| M7633-25MG | 04061835557745 |