L7527
Lipoprotein, very low density from human plasma
≥95% (SDS-PAGE), solution
Synonym(s):
Pre-β-lipoprotein, VLDL, Very low density lipoprotein
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About This Item
Biochem/physiol Actions
Inhibits DNA synthesis in lymphocytes activated by the nonspecific mitogen concanavalin A (Con A).
VLDL (Very low density lipoprotein) may be used to study the mechanisms and effects of very low density receptors (VLDLR). VLDL is used as a potential source of fatty acids that support cardiac energy metabolism. VLDL is often studied to differentiate its effects from those of chylomicrons.
Physical form
Solution in 150 mM NaCl and 0.01% EDTA, pH 7.4
Other Notes
View more information on lipoprotein function and lipid transport at www.sigma-aldrich.com/enzymeexplorer
Storage Class
12 - Non Combustible Liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Akifumi Kushiyama et al.
Arteriosclerosis, thrombosis, and vascular biology, 33(8), 1986-1993 (2013-05-25)
Resistin-like molecule (RELM) β is a secretory protein homologous to resistin and reportedly contributes to local immune response regulation in gut and bronchial epithelial cells. However, we found that activated macrophages also express RELMβ and thus investigated the role of
Samata Tiwari et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(5), 1079-1086 (2012-04-21)
Steady increase in the incidence of atherosclerosis is becoming a major concern not only in the United States but also in other countries. One of the major risk factors for the development of atherosclerosis is high concentrations of plasma low-density
Gwang-Woong Go et al.
The Yale journal of biology and medicine, 85(1), 19-28 (2012-03-31)
The LDLR family of proteins is involved in lipoproteins trafficking. While the role of LDLR in cardiovascular disease has been widely studied, only recently the role of other members of the LDLR proteins in lipoprotein homeostasis and atherosclerosis has emerged.