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Merck
CN

I127

ICI 118,551 hydrochloride

≥98% (HPLC), powder, β2 inverse agonist

Synonym(s):

(2R,3R)-rel-3-isopropylamino-1-(7-methylindan-4-yloxy)-butan-2-ol hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C17H27NO2 · HCl
CAS Number:
72795-01-8
Molecular Weight:
313.86
UNSPSC Code:
12352200
PubChem Substance ID:
24277782
NACRES:
NA.77
MDL number:
MFCD00153812

Key Documents

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Product Name

ICI 118,551 hydrochloride, ≥98% (HPLC), powder

SMILES string

Cl.CC(C)N[C@@H](C)[C@@H](O)COc1ccc(C)c2CCCc12

InChI

1S/C17H27NO2.ClH/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17;/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3;1H/t13-,16-;/m0./s1

InChI key

KBXMBGWSOLBOQM-LINSIKMZSA-N

assay

≥98% (HPLC)

form

powder

storage condition

desiccated

color

white

solubility

H2O: >10 mg/mL

Quality Level

100

Gene Information

human ... ADRB2(154)

Related Categories

Application

ICI 118,551 hydrochloride has been used:
  • to block β-adrenergic signaling in various experiments
  • to counteract degradation by endogenous T-lymphocyte monoamine oxidases
  • to determine the specific receptor subtype necessary for isoproterenol to induce up-regulation of gene transcripts

Biochem/physiol Actions

ICI 118,551 has been used to treat vasomotor migraines and somatic troubles related to anxiety state.
ICI 118,551 hydrochloride is a highly selective β2-adrenoceptor antagonist.

Disclaimer

Hygroscopic

Features and Benefits

This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000457654
0000457653
0000457653
0000457654
0000450238

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The Journal of biological chemistry, 288(42), 30734-30741 (2013-09-18)
Functional autoantibodies to the autonomic receptors are increasingly recognized in the pathophysiology of cardiovascular diseases. To date, no human activating monoclonal autoantibodies to these receptors have been available. In this study, we describe for the first time a β2-adrenergic receptor
R M Booze et al.
The Journal of pharmacology and experimental therapeutics, 249(3), 911-920 (1989-06-01)
The localization and number of beta adrenergic receptors were directly compared in the brains of rats and guinea pigs. The time course of association and saturability of [125I]cyanopindolol (CYP) binding to slide-mounted tissue sections was similar in rats (Kd =
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