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G1660

Galanthamine hydrobromide

Name: Galanthamine hydrobromide
Brand: SIGMA

From plant (Ungeria victoris), ≥94% (HPLC), Cholinesterase inhibitor, powder

Synonym(s):

Galantamine hydrobromide

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About This Item

Empirical Formula (Hill Notation):

C₁₇H₂₁NO₃ · HBr

CAS Number:

1953-04-4

Molecular Weight:

368.27

UNSPSC Code:

12352116

PubChem Substance ID:

24895074

NACRES:

NA.32

EC Number:

217-780-5

MDL number:

MFCD00067672

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Properties

Product Name

Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC)

biological source

plant (Ungeria victoris)

Quality Segment

100

assay

≥94% (HPLC)

form

powder

mp

270 °C

solubility

DMSO: soluble 10 mg/mL, clear, colorless, water: soluble 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChI key

QORVDGQLPPAFRS-XPSHAMGMSA-N

Gene Information

human ... ACHE(43)

Description

General description

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).

Application

Galanthamine hydrobromide from Lycoris sp. has been used-

as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE
as a positive control in the screening of AChE inhibitors
as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides

Biochem/physiol Actions

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Pictograms

GHS06

Signal Word

Danger

Hazard Codes

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)