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E7280

Elafin

recombinant, expressed in Saccharomyces cerevisiae, powder, >90% (by MS, HPLC and SDS-PAGE),

Synonym(s):

Elastase-specific inhibitor, skin-derived antileukoprotease

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About This Item

UNSPSC Code:
12352202
NACRES:
NA.77
MDL number:
MFCD00146824
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Product Name

Elafin human, >90% (by MS, HPLC and SDS-PAGE), recombinant, expressed in Saccharomyces cerevisiae

recombinant

expressed in Saccharomyces cerevisiae

Quality Level

200

assay

>90% (by MS, HPLC and SDS-PAGE)

form

powder

potency

1.7 x 10-10 M Ki (human leukocyte elastase), 4.2 x 10-10 M Ki (human proteinase 3)

mol wt

~6 kDa

UniProt accession no.

P19957

antibiotic activity spectrum

Gram-negative bacteria, Gram-positive bacteria

mode of action

enzyme | inhibits

shipped in

ambient

storage temp.

−20°C

Gene Information

human ... PI3(5266)

General description

Chemical structure: peptide

Biochem/physiol Actions

Exhibits co-existent antimicrobial and antiproteolytic activities.1 Inhibits WAP-type four-disulfide core (WFDC) domain containing elastases. Antimicrobial spectrum: Gram-positive and Gram-negative bacteria.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage.
Inhibitor of human leukocyte elastase and proteinase 3, originally isolated from the skin of patients with psoriasis. May protect against certain autoimmune tissue damage. An elastase inhibitor which is an active fragment of elafin, as well as elafin itself, can also be found in bronchial carcinoma secretions.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

常规特殊物品

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Certificates of Analysis (COA)

Lot/Batch Number
0000519386
0000519386
0000269791
0000269791
SLCN7898

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Articles

Elastase Function and Importance

Elastase application index for understanding leukocyte elastase, a 29KDa serine endoprotease.

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Proteases play an essential role in the pathophysiology of inflammatory bowel disease (IBD), contributing to the intestinal mucosal lesions through the degradation of the extracellular matrix and alteration of the barrier function. Ulcerative colitis (UC) is characterized by an extensive
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Clinical science (London, England : 1979), 134(13), 1679-1696 (2020-07-08)
Type 1 diabetes is an autoimmune disease resulted from self-destruction of insulin-producing pancreatic β cells. However, the pathological pathways that trigger the autoimmune destruction remain poorly understood. Clinical studies have demonstrated close associations of neutrophils and neutrophil elastase (NE) with
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Global Trade Item Number

SKUGTIN
E7280-100UG04061833605035