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Merck
CN

C1254

Sodium cholate hydrate

from bovine and/or ovine bile, ≥99%

Synonym(s):

3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid sodium salt, Cholalic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C24H39NaO5 · xH2O
CAS Number:
206986-87-0
Molecular Weight:
430.55 (anhydrous basis)
UNSPSC Code:
12161900
NACRES:
NA.25
PubChem Substance ID:
24892390
EC Number:
206-643-5
Beilstein/REAXYS Number:
3582354
MDL number:
MFCD00150749

Key Documents

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Product Name

Sodium cholate hydrate, from bovine and/or ovine bile, ≥99%

InChI key

MUVVIYFKOVLQHL-RCVKHMDESA-M

InChI

1S/C24H40O5.Na.H2O/c1-13(4-7-21(28)29)16-5-6-17-22-18(12-20(27)24(16,17)3)23(2)9-8-15(25)10-14(23)11-19(22)26;;/h13-20,22,25-27H,4-12H2,1-3H3,(H,28,29);;1H2/q;+1;/p-1/t13-,14+,15-,16-,17+,18+,19-,20+,22+,23+,24-;;/m1../s1

SMILES string

O.[Na+].C[C@H](CCC([O-])=O)C1CCC2C3[C@H](O)CC4C[C@H](O)CC[C@]4(C)C3C[C@H](O)[C@]12C

biological source

bovine and/or ovine bile

description

anionic

assay

≥99%

form

powder

mol wt

micellar avg mol wt 900-1300

aggregation number

2-3

technique(s)

DNA purification: suitable
RNA purification: suitable
western blot: suitable

CMC

9-15 mM (20-25°C)

solubility

water: 100 mg/mL, clear, colorless to light yellow

HLB

18

Quality Level

200

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Application

Sodium cholate hydrate has been used in a study to assess the effect of phospholipid formulation and surfactants on the dermal delivery of hydrophilic drugs from elastic liposomes. It has also been used in a study to investigate the elastic deformable vesicles, transfersomes, for transdermal drug delivery.

Biochem/physiol Actions

Bile Salt

Features and Benefits

  • Suitable for Western blotting
  • Suitable for DNA and RNA purification
  • High purity product for research applications

General description

Sodium cholate hydrate, a non-denaturing anionic detergent, plays a crucial role in biochemical research, particularly in protein solubilization and membrane permeabilization, making it essential for protein extraction and purification, especially when dealing with membrane proteins and protein complexes. Derived from cholic acid, a prevalent human bile acid, sodium cholate hydrate′s water solubility and its applications extend to investigating the effects of various substances on cell cultures, making it a versatile tool in laboratory research.

Other Notes

For additional information on our range of Biochemicals, please complete this form.

hcodes

H412

Hazard Classifications

Aquatic Chronic 3

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000523079
0000523079
0000496655
0000496655
0000496656

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Transfersomes for transdermal drug delivery
Benson, H.
Expert Opinion on Drug Delivery, 3, 727-727 (2005)
Kevin B Ita et al.
The Journal of pharmacy and pharmacology, 59(9), 1215-1222 (2007-09-22)
The effect of phospholipid formulation and choice of surfactant on skin permeation of selected hydrophilic drugs from elastic liposomes across human epidermal membrane has been studied. Sodium cholate and various concentrations of phosphatidylcholine were used for the preparation of liposomes
Yan Qiao et al.
Langmuir : the ACS journal of surfaces and colloids, 27(17), 11090-11097 (2011-07-19)
We report a facile method to synthesize water-soluble gold nanoparticles (AuNPs) using a biosurfactant sodium cholate as reducing reagents and protective groups in aqueous solution at ambient temperature. The diameters (13-70 nm) of uniform AuNPs can be readily adjusted by
Ching-Wei Lin et al.
Nature communications, 10(1), 2874-2874 (2019-06-30)
Covalent doping of single-walled carbon nanotubes (SWCNTs) can modify their optical properties, enabling applications as single-photon emitters and bio-imaging agents. We report here a simple, quick, and controllable method for preparing oxygen-doped SWCNTs with desirable emission spectra. Aqueous nanotube dispersions
Li Lei et al.
Current protocols in protein science, 84, 29-29 (2016-04-03)
Fish and human cytochrome P450 (P450) 17A1 catalyze both steroid 17α-hydroxylation and 17α,20-lyase reactions. Fish P450 17A2 catalyzes only 17α-hydroxylation. Both enzymes are microsomal-type P450s, integral membrane proteins that bind to the membrane through their N-terminal hydrophobic segment, the signal
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