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Merck
CN

B161

B-HT 933 dihydrochloride

≥98% (HPLC), solid

Synonym(s):

6-Ethyl-5,6,7,8-tetrahydro-4H-oxazolo[4,5-d]azepin-2-amine dihydrochloride, Azepexole dihydrochloride

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About This Item

Empirical Formula (Hill Notation):
C9H15N3O · 2HCl
CAS Number:
36067-72-8
Molecular Weight:
254.16
UNSPSC Code:
12352200
PubChem Substance ID:
24277762
MDL number:
MFCD01529923

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Product Name

B-HT 933 dihydrochloride, ≥98% (HPLC), solid

InChI

1S/C9H15N3O.2ClH/c1-2-12-5-3-7-8(4-6-12)13-9(10)11-7;;/h2-6H2,1H3,(H2,10,11);2*1H

SMILES string

Cl.Cl.CCN1CCc2nc(N)oc2CC1

InChI key

HBLPYIOKPJVFQW-UHFFFAOYSA-N

assay

≥98% (HPLC)

form

solid

color

white to off-white

solubility

H2O: >20 mg/mL

Gene Information

human ... ADRA2A(150), ADRA2B(151), ADRA2C(152)

Biochem/physiol Actions

Selective α2-adrenoceptor agonist.

Features and Benefits

This compound is featured on the α2-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Storage Class

13 - Non Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
037K47132
037K47131
037K4713
017K4718
070K4704

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S Sarkar et al.
American journal of physiology. Regulatory, integrative and comparative physiology, 281(6), R1966-R1974 (2001-11-14)
The placenta expresses high levels of 11beta-hydroxysteroid dehydrogenase type 2 (11betaHSD2) that converts cortisol into inactive 11-keto metabolites and effectively protects the developing fetus from maternal cortisol during pregnancy. Impairment of this glucocorticoid barrier has adverse effects on fetal outcomes.
F A Gesek
Hypertension (Dallas, Tex. : 1979), 33(1 Pt 2), 524-529 (1999-02-04)
Alpha-Adrenergic receptor (AR) activation enhances sodium retention in certain forms of hypertension. The objective of the present study was to understand the role of alpha-ARs in regulating sodium transport by distal tubules (DT). DT cells were isolated from kidneys of
D Walter Wray et al.
The Journal of physiology, 555(Pt 2), 545-563 (2003-12-25)
The mechanisms underlying metabolic inhibition of sympathetic responses within exercising skeletal muscle remain incompletely understood. The aim of the present study was to test whether alpha(2)-adrenoreceptor-mediated vasoconstriction was more sensitive to metabolic inhibition than alpha(1)-vasoconstriction during dynamic knee-extensor exercise. We
R F Schäfers et al.
Pharmacogenetics, 11(6), 461-470 (2001-08-16)
A C825T polymorphism was recently identified in the gene for the G-protein beta3 subunit, the T-allele being associated with hypertension. To better understand the underlying pathophysiological mechanisms, we compared the haemodynamics of young healthy males with and without the T-allele.
H Nielsen et al.
The Journal of pharmacology and experimental therapeutics, 260(2), 637-643 (1992-02-01)
Human s.c. resistance arteries (internal diameters 158-353 microns) were mounted in a microvascular myograph, and experiments were designed to examine the calcium pools utilized by selective stimulation of alpha-1 and alpha-2 adrenoceptors. In a concentration-dependent manner, phenylephrine and B-HT 933
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