All Photos(5)
Synonym(s):
Sulfourea, Thiocarbamide
Linear Formula:
NH2CSNH2
CAS Number:
Molecular Weight:
76.12
Beilstein:
605327
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21
Recommended Products
Quality Level
product line
ReagentPlus®
Assay
≥99.0%
mp
170-176 °C (lit.)
SMILES string
NC(N)=S
InChI
1S/CH4N2S/c2-1(3)4/h(H4,2,3,4)
InChI key
UMGDCJDMYOKAJW-UHFFFAOYSA-N
Gene Information
mouse ... Ephx2(13850)
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Related Categories
General description
Thiourea is an analogue of urea, containing sulphur.
Application
Thiourea has been used:
- as a component in ice cold sample buffer for protein analysis
- in intracellular extraction buffer for the extraction of soluble intracellular proteins
- as a component of electrophoresis buffer
Chaotropic agent; strong denaturant. Increases solubility and recovery of proteins
Biochem/physiol Actions
Thiourea is a free radical scavenger of the peroxide radical. It was shown to inhibit lipid peroxidation and ultraviolet (UV)-induced crosslinking of collagen. Bud dormancy in plants can be inhibited by thiourea, which is used as a growth stimulator. It is also known to be used in the treatment of hyperthyroidism.
Legal Information
ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
危险化学品
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Feline hypertrophic cardiomyopathy associated with the p. A31P Mutation in cMyBP-C is caused by production of mutated cMyBP-C with reduced binding to actin
Godiksen MTN, et al.
Open Journal of Veterinary Medicine, 3(02), 95-95 (2013)
Synergistic effects of glucose and ultraviolet irradiation on the physical properties of collagen
Ohan MP, et al.
Journal of Biomedical Materials Research, 60(3), 384-391 (2002)
Extraction of Intracellular and Cell Wall Proteins from Leaves and Roots of Harsh Hakea
Shane MW and Plaxton WC
Journal of Experimental Botany (2014)
Protocol: Optimised methodology for isolation of nuclei from leaves of species in the Solanaceae and Rosaceae families
Sikorskaite S, et al.
Plant methods, 9(1), 31-31 (2013)
Yoshiji Takemoto
Chemical & pharmaceutical bulletin, 58(5), 593-601 (2010-05-13)
We have developed several multifunctional thiourea catalysts bearing a tertiary amine or an 1,2-amino alcohol in expectation of their synchronous activation of a nucleophile and an electrophile through both acid-base and hydrogen-bonding interactions. From these studies, it was revealed that
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