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D6750

Sigma-Aldrich

Sodium deoxycholate

≥97% (titration)

Synonym(s):

3α,12α-Dihydroxy-5β-cholanic acid sodium salt, 7-Deoxycholic acid sodium salt, Desoxycholic acid sodium salt

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About This Item

Empirical Formula (Hill Notation):
C24H39NaO4
CAS Number:
302-95-4
Molecular Weight:
414.55
Beilstein:
3581950
EC Number:
206-132-7
MDL number:
MFCD00064139
UNSPSC Code:
12161900
PubChem Substance ID:
24894044
NACRES:
NA.21

biological source

bovine bile

Quality Level

200

description

anionic

Assay

≥97% (titration)

form

powder

mol wt

micellar avg mol wt 1200-5000

aggregation number

3-12

CMC

2-6 mM (20-25°C)

solubility

water: 50 mg/mL, clear, colorless to light yellow

HLB

16

functional group

carboxylic acid

shipped in

ambient

storage temp.

room temp

SMILES string

[Na+].[H][C@]12CC[C@@]3([H])[C@]4([H])CC[C@H]([C@H](C)CCC([O-])=O)[C@@]4(C)[C@@H](O)C[C@]3([H])[C@@]1(C)CC[C@@H](O)C2

InChI

1S/C24H40O4.Na/c1-14(4-9-22(27)28)18-7-8-19-17-6-5-15-12-16(25)10-11-23(15,2)20(17)13-21(26)24(18,19)3;/h14-21,25-26H,4-13H2,1-3H3,(H,27,28);/q;+1/p-1/t14-,15-,16-,17+,18-,19+,20+,21+,23+,24-;/m1./s1

InChI key

FHHPUSMSKHSNKW-SMOYURAASA-M

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General description

Deoxycholic acid sodium salt, also known as Sodium Deoxycholate, is a highly versatile ionic detergent utilized for its exceptional ability to solubilize membrane-bound proteins and lyse cells. Its mechanism involves disrupting cell membranes and dissolving hydrophobic molecules, making it an invaluable reagent in scientific research applications. In protein research, it plays a pivotal role in solubilizing proteins, particularly those embedded in membranes, enabling their extraction, purification, and subsequent analysis.

Moreover, Sodium Deoxycholate extends its utility to nucleic acid extraction from cells and tissues. By lysing cells and disrupting cellular structures, it facilitates the release and purification of nucleic acids, proving valuable in cell biology and biochemical research. Beyond these applications, its effectiveness in cell lysis processes positions it as a valuable tool for breaking down cells and releasing their contents, finding applications in diverse biological studies, encompassing microscopy, cell biology, and biochemical research.

Application

Sodium deoxycholate has been used in the lysis buffer prepared for brown adipose tissue. It has been used in the decellularization of aortic valvular conduit.

Biochem/physiol Actions

Solubilizes fats for absorption in the intestines.

Features and Benefits

Highly versatile surfactant for your cell biology and biochemical research

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
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Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Methods in Cell Biology (1974)
Chemistry and biology of bile acids.
Mukhopadhyay S and Maitra U
Current Science, 87, 1666-1683 (2004)
Development of decellularized aortic valvular conduit coated by heparin-SDF-1a multilayer.
Zhou J et al.
The Annals of Thoracic Surgery, 99, 612-612 (2015)
L L Liu et al.
Oncogene, 33(24), 3140-3150 (2013-07-16)
Prostate tumors develop resistance to androgen deprivation therapy (ADT) by multiple mechanisms, one of which is to express constitutively active androgen receptor (AR) splice variants lacking the ligand-binding domain. AR splice variant 7 (AR-V7, also termed AR3) is the most
Jingxin Zhou et al.
The Annals of thoracic surgery, 99(2), 612-618 (2014-12-17)
Decellularization can reduce the immune response to aortic valve allograft tissue, but the thrombogenicity and in vivo remolding of these grafts remain controversial. The aim of the present study was to modify the surface of decellularized valvular conduits with heparin-stromal
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