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Compare (4)
(+)-JQ1 ≥98% (HPLC)
Sigma-Aldrich
SML1524
(+)-JQ1
(-)-JQ1 ≥95% (HPLC)
Sigma-Aldrich
SML1525
(-)-JQ1
(+/-)-JQ1 ≥98% (HPLC)
Sigma-Aldrich
SML0974
(+/-)-JQ1
(+)-JQ-1 carboxylic acid ≥95% (HPLC)
Sigma-Aldrich
SML2623
(+)-JQ-1 carboxylic acid
≥98% (HPLC)
≥95% (HPLC)
≥98% (HPLC)
≥95% (HPLC)

Description

Synonyms
(S)-(+)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6S)-
(R)-(-)-tert-Butyl 2-(4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)acetate, 6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, 1,1-dimethylethyl ester, (6R)-
N-(2′,5′-Dimethoxy[1,1′-biphenyl]-4-yl)-3-fluoro-4-pyridinecarboxamide, (+/-)-SGCBD01, [(R,S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-1-thia-5,7,8,9a-tetraaza-cyclopenta[e]azulen-6-yl]-acetic acid tert-butyl ester
(6S)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, (S)-[4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-yl]acetic acid, 2-[(6S,Z)-4-(4-Chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]acetic acid
CAS Number
1268524-70-4
1268524-71-5
1268524-69-1
202592-23-2
Molecular Formula
Empirical Formula (Hill Notation)
: C23H25ClN4O2S
Empirical Formula (Hill Notation)
: C23H25ClN4O2S
Empirical Formula (Hill Notation)
: C23H25ClN4O2S
Empirical Formula (Hill Notation)
: C19H17ClN4O2S
Molecular Weight
: 456.99
Molecular Weight
: 456.99
Molecular Weight
: 456.99
Molecular Weight
: 400.88
MDL Number
MFCD22683748
MFCD22124456
MFCD23726614
MFCD28167916
Quality Designations
100
100
100

Properties

Assay:
≥98% (HPLC)
Assay:
≥95% (HPLC)
Assay:
≥98% (HPLC)
Assay:
≥95% (HPLC)
color:
white to beige
color:
white to beige
color:
white to beige
color:
white to beige
drug control:
drug control:
drug control:
regulated under CDSA - not available from Sigma-Aldrich Canada
drug control:
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m0/s1
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3/t17-/m1/s1
InChI:
1S/C23H25ClN4O2S/c1-12-13(2)31-22-19(12)20(15-7-9-16(24)10-8-15)25-17(11-18(29)30-23(4,5)6)21-27-26-14(3)28(21)22/h7-10,17H,11H2,1-6H3
InChI:
1S/C19H17ClN4O2S/c1-9-10(2)27-19-16(9)17(12-4-6-13(20)7-5-12)21-14(8-15(25)26)18-23-22-11(3)24(18)19/h4-7,14H,8H2,1-3H3,(H,25,26)/t14-/m0/s1
InChI key:
DNVXATUJJDPFDM-KRWDZBQOSA-N
InChI key:
DNVXATUJJDPFDM-QGZVFWFLSA-N
InChI key:
DNVXATUJJDPFDM-UHFFFAOYSA-N
InChI key:
LJOSBOOJFIRCSO-AWEZNQCLSA-N
form:
powder
form:
powder
form:
powder
form:
powder
SMILES string:
O=C(OC(C)(C)C)C[C@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1
SMILES string:
O=C(OC(C)(C)C)C[C@@H]1C2=NN=C(C)N2C(SC(C)=C3C)=C3C(C4=CC=C(Cl)C=C4)=N1
SMILES string:
CC1=NN=C2N1C3=C(C(C)=C(C)S3)C(C4=CC=C(Cl)C=C4)=NC2CC(OC(C)(C)C)=O
SMILES string:
[s]1c2c(c(c1C)C)C(=N[C@H](c4[n]2c(nn4)C)CC(=O)O)c3ccc(cc3)Cl
solubility:
DMSO: 20 mg/mL, clear
solubility:
DMSO: 20 mg/mL, clear
solubility:
DMSO: 2 mg/mL, clear (warmed)
solubility:
DMSO: 2 mg/mL, clear
storage temp.:
2-8°C
storage temp.:
2-8°C
storage temp.:
2-8°C
storage temp.:
2-8°C
Quality Level:
100
Quality Level:
100
Quality Level:
100
Quality Level:

Usage and Safety

Application
(+)-JQ1 has been used in flow cytometry assay, cell viability assay and quantitative PCR assay in order to investigate on the reversal of HIV-1 latency.
(±)-JQ1 has been used to study its effect on adipogenesis, by analyzing the its impact on the regulation of genes involved in this process especially peroxisome proliferator-activated receptor (PPAR-g), the CCAAT/enhancer-binding protein (C/EBPa) and, STAT5A and B. JQ1 has been used in drug binding assays as a chemical inhibitor of BRD4 to study the CRBN’s substrate recruiting function in mouse and human.
Risk and Safety
Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable

Storage Class Code:

11 - Combustible Solids

WGK:

WGK 3

Flash Point(F):

Not applicable

Flash Point(C):

Not applicable