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Merck
CN

G2417

Gabexate mesylate

analytical standard, for drug analysis

Synonym(s):

4-[[6-[(Aminoiminomethyl)amino]-1-oxohexyl]oxyl]benzoic acid ethyl ester mesylate salt, FOY, Megacart

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About This Item

Empirical Formula (Hill Notation):
C16H23N3O4 · CH4O3S
CAS Number:
56974-61-9
Molecular Weight:
417.48
MDL number:
MFCD00210299
UNSPSC Code:
41116107
PubChem Substance ID:
329799903
NACRES:
NA.24

Key Documents

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Quality Level

200

form

solid

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

application(s)

forensics and toxicology
pharmaceutical (small molecule)
veterinary

format

neat

SMILES string

CS(O)(=O)=O.CCOC(=O)c1ccc(OC(=O)CCCCCNC(N)=N)cc1

InChI

1S/C16H23N3O4.CH4O3S/c1-2-22-15(21)12-7-9-13(10-8-12)23-14(20)6-4-3-5-11-19-16(17)18;1-5(2,3)4/h7-10H,2-6,11H2,1H3,(H4,17,18,19);1H3,(H,2,3,4)

InChI key

DNTNDFLIKUKKOC-UHFFFAOYSA-N

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General description

Gabexate mesylate is a non-antigenic synthetic inhibitor of trypsin-like serine proteinases, which finds therapeutic applications in the treatment of disseminated intravascular coagulation and pancreatitis. It also plays the role of an anticoagulant in hemodialysis therapy.

Application

Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Storage Class Code

11 - Combustible Solids

WGK

WGK 2

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

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S Aosasa et al.
Shock (Augusta, Ga.), 15(2), 101-105 (2001-02-28)
If the inflammatory response becomes excessive or uncontrolled by some stimuli, inappropriate inflammatory responses occur. Monocytes are extremely important cells for regulating the cytokine network and tumor necrosis factor alpha (TNFalpha) and interleukin- (IL) 10, which are mainly synthesized by
Tomoki Nishiyama et al.
The American journal of emergency medicine, 30(7), 1219-1223 (2011-12-30)
We hypothesized that antithrombin is more effective for disseminated intravascular coagulation (DIC) than is gabexate mesilate, which is a protease inhibitor, suggested from the previous studies. Initially, we compared the effects of antithrombin and gabexate mesilate for treating infection-related DIC.
Dalya M Lateef et al.
Physiology & behavior, 105(3), 829-834 (2011-11-04)
We have shown that vagotomy (VGX) attenuates the reduction of meal size (MS) produced by cholecystokinin (CCK) -8 and -33 and that celiaco-mesenteric ganglionectomy (CMGX) attenuates the prolongation of the intermeal interval (IMI) produced by CCK-33. Here, we report the
Gabexate mesylate inhibition of serine proteases: Thermodynamic and computer?graphics analysis.
Menegatti E, et al.
Journal of Pharmaceutical Sciences, 75(12), 1171-1174 (1986)
Hirofumi Noguchi et al.
Cell transplantation, 21(2-3), 509-516 (2012-07-17)
For islet transplantation, maintaining organ viability after pancreas procurement is critically important for optimal graft function and survival. We recently reported that islet yield was significantly higher in the modified ET-Kyoto (MK) solution, which includes a trypsin inhibitor (ulinastatin), compared
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Articles

Chymotrypsin

Analytical Enzyme Chymotrypsin: Chymotrypsin is produced in the acinar cells of the pancreas as the inactive precursor, chymotrypsinogen.

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