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E4378

Sigma-Aldrich

Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid

≥97.0%

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Synonym(s):
EGTA, Egtazic acid, Ethylene-bis(oxyethylenenitrilo)tetraacetic acid, Glycol ether diamine tetraacetic acid
Linear Formula:
[-CH2OCH2CH2N(CH2CO2H)2]2
CAS Number:
67-42-5
Molecular Weight:
380.35
Beilstein:
1717370
EC Number:
200-651-2
MDL number:
MFCD00004291
UNSPSC Code:
12352106
PubChem Substance ID:
24278421
NACRES:
NA.77

biological source

synthetic (organic)

Quality Level

400

Assay

≥97.0%

form

powder

reaction suitability

reagent type: chelator

loss

≤1.0% loss on drying

mp

241 °C (dec.) (lit.)

solubility

1 M NaOH: 1.1 g/10 mL, clear, colorless

storage temp.

room temp

SMILES string

OC(=O)CN(CCOCCOCCN(CC(O)=O)CC(O)=O)CC(O)=O

InChI

1S/C14H24N2O10/c17-11(18)7-15(8-12(19)20)1-3-25-5-6-26-4-2-16(9-13(21)22)10-14(23)24/h1-10H2,(H,17,18)(H,19,20)(H,21,22)(H,23,24)

InChI key

DEFVIWRASFVYLL-UHFFFAOYSA-N

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Application

Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid has been used as a component of:
  • ice-cold cardioplegia solution for transverse aortic constriction in rats
  • ice-cold lysis buffer for protein extraction and whole extract cells
  • buffer A, B and, C for the extraction of mitochondria from HEK293F cells

A chelating agent useful for the determination of calcium in the presence of magnesium.

Biochem/physiol Actions

Ethylene glycol-bis(2-aminoethylether)-N,N,N′,N′-tetraacetic acid A is a chelating agent used for the determination of calcium in the presence of magnesium.

Physical properties

solubility in water increases with pH

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

WGK

WGK 2

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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