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Merck
CN

21192

Calcium ionophore I

Selectophore, function tested, ≥99.0%

Synonym(s):

(−)-(R,R)-N,N′-Bis-[11-(ethoxycarbonyl)undecyl]-N,N′,4,5-tetramethyl-3,6-dioxaoctane-diamide, Diethyl N,N′-[(4R,5R)-4,5-dimethyl-1,8-dioxo-3,6-dioxaoctamethylene]bis(12-methylaminododecanoate), ETH 1001

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About This Item

Empirical Formula (Hill Notation):
C38H72N2O8
CAS Number:
Molecular Weight:
684.99
UNSPSC Code:
26111700
NACRES:
NB.61
PubChem Substance ID:
EC Number:
261-449-8
Beilstein/REAXYS Number:
2343275
MDL number:
Assay:
≥99.0% (HPLC)
≥99.0%
Quality level:
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Product Name

Calcium ionophore I, Selectophore, function tested, ≥99.0%

InChI key

CJAONIOAQZUHPN-KKLWWLSJSA-N

InChI

1S/C38H72N2O8/c1-7-45-37(43)27-23-19-15-11-9-13-17-21-25-29-39(5)35(41)31-47-33(3)34(4)48-32-36(42)40(6)30-26-22-18-14-10-12-16-20-24-28-38(44)46-8-2/h33-34H,7-32H2,1-6H3/t33-,34-/m1/s1

SMILES string

CCOC(=O)CCCCCCCCCCCN(C)C(=O)CO[C@H](C)[C@@H](C)OCC(=O)N(C)CCCCCCCCCCCC(=O)OCC

description

for ion-selective electrodes

product line

Selectophore

assay

≥99.0% (HPLC)
≥99.0%

quality

function tested

Quality Level

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Application

Selected application examples
Calcium ionophore I (ETH 1001) was used in an experimental study, conducted to determine the intracellular and extracellular changes of calcium ions in hypoxia and ischemia in rat brain.

General description

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Other Notes

Used as ionophore in membrane electrodes for the determination of Ca2+-activities; Useful for transport studies in biological membranes.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Legal Information

Selectophore is a trademark of Merck KGaA, Darmstadt, Germany

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves


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P Caroni et al.
Biochimica et biophysica acta, 470(3), 437-445 (1977-11-01)
The effect of a synthetic neutral ligand on the Ca2+ permeability of several biological membranes has been investigated. The ligand had been previously shown to possess Ca2+ -ionophoric activities in artificial phospholipid membranes. The neutral ionophore is able to transport
Rita I Jabr et al.
Pflugers Archiv : European journal of physiology, 468(11-12), 1945-1955 (2016-10-21)
Cardiac arrhythmias are associated with raised intracellular [Ca2+] and slowed action potential conduction caused by reduced gap junction (GJ) electrical conductance (Gj). Ventricular GJs are composed of connexin proteins (Cx43), with Gj determined by Cx43 phosphorylation status. Connexin phosphorylation is
I A Silver et al.
The Journal of general physiology, 95(5), 837-866 (1990-05-01)
Changes in intra- and extracellular free calcium concentration were evaluated with ion-selective microelectrodes during periods of anoxia and ischemia in three different regions of intact rat brain. Recordings stable for at least 2 min and in most cases for 4-6
W. Simon et al.
Annals of the New York Academy of Sciences, 307, 52-52 (1978)
N Abuaf et al.
Journal of allergy, 2012, 580873-580873 (2011-12-22)
Background. An in vitro basophil activation test, based on the detection of CD63 upregulation induced by NSAIDs, has been described. Its clinical significance remains controversial. Objectives. In patients with a history of nonallergic NSAID hypersensitivity, stratified according to the severity

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