VKORC1
vitamin K epoxide reductase complex, subunit 1
Synonyms:
EDTP308, IMAGE3455200, MST134, MST576, VKCFD2, VKOR
Species:
Human VKORC1 (79001), Mouse Vkorc1 (27973), Rat Vkorc1 (309004), cow VKORC1 (445422), domestic guinea pig Vkorc1 (100717597), naked mole-rat Vkorc1 (101712530), dog VKORC1 (479775), Zebrafish vkorc1 (100000559), chicken VKORC1 (404205), domestic cat VKORC1 (101089669)
UniProtKB ID:
Gene ID:
- Human(79001) Summary: Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
- Mouse(27973) vitamin K epoxide reductase complex, subunit 1
- Rat(309004) vitamin K epoxide reductase complex, subunit 1
- cow(445422) vitamin K epoxide reductase complex, subunit 1
- domestic guinea pig(100717597) vitamin K epoxide reductase complex, subunit 1
- naked mole-rat(101712530) vitamin K epoxide reductase complex, subunit 1
- dog(479775) vitamin K epoxide reductase complex, subunit 1
- Zebrafish(100000559) vitamin K epoxide reductase complex, subunit 1
- chicken(404205) vitamin K epoxide reductase complex, subunit 1
- domestic cat(101089669) vitamin K epoxide reductase complex, subunit 1
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