PRS4203
Anti-Presenilin1 antibody produced in rabbit
affinity isolated antibody, buffered aqueous solution
别名:
Anti-γ-Secretase subunit presenilin-1, Anti-PS1, Anti-PSEN1, Anti-Presenilin 1
产品名称
Anti-Presenilin1 antibody produced in rabbit, affinity isolated antibody, buffered aqueous solution
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
form
buffered aqueous solution
species reactivity
mouse, rat, human
technique(s)
immunofluorescence: suitable
immunohistochemistry: suitable
indirect ELISA: suitable
western blot: suitable
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Quality Level
Gene Information
human ... PSEN1(5663)
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Immunogen
a 23 amino acid peptide from near the carboxy-terminus of human presenilin1.
Other Notes
The action of this antibody can be blocked using blocking peptide SBP4203.
Physical form
Solution in phosphate buffered saline containing 0.02% sodium azide
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存储类别
10 - Combustible liquids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
法规信息
常规特殊物品
此项目有
Huang Huang et al.
Age (Dordrecht, Netherlands), 38(4), 303-322 (2016-07-22)
Transgenic APPSwe/PS1dE9 (APP/PS1) mice that overproduce amyloid beta (Aβ) are extensively used in the studies of pathogenesis and experimental therapeutics and new drug screening for Alzheimer's disease (AD). However, most of the current literature uses young or adult APP/PS1 mice.
Weixi Feng et al.
Alzheimer's research & therapy, 12(1), 125-125 (2020-10-04)
Soluble beta-amyloid (Aβ) can be cleared from the brain through various mechanisms including enzymatic degradation, glial cell phagocytosis, transport across the blood-brain barrier, and glymphatic clearance. However, the relative contribution of each clearance system and their compensatory effects in delaying
Linmei Wang et al.
Brain pathology (Zurich, Switzerland), 29(2), 176-192 (2018-09-08)
The imbalance between production and clearance of amyloid-beta (Aβ) is a key step in the onset and development of Alzheimer's disease (AD). Therefore, reducing Aβ accumulation in the brain is a promising therapeutic strategy for AD. The recently discovered glymphatic
Min Cao et al.
CNS neuroscience & therapeutics, 24(3), 202-211 (2017-12-24)
Social isolation increases the onset of Alzheimer's disease (AD). Environmental enrichment, a complicated social and physical construct, plays beneficial effects on brain plasticity and function. This study was designed to determine whether physical enrichment can reduce the deleterious consequences of social
Shuang Zhai et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 37(7), e23034-e23034 (2023-06-21)
Animal behavioral tests are often conducted during the day. However, rodents are nocturnal animals and are primarily active at night. The aim of this study was to determine whether there are diurnal changes in cognitive and anxiety-like performance of mice
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